We simuleren interstellaire wolken met speciale plasma-expansies en chemische reacties op ijzige stofdeeltjes in ultrahoogvacuümopstellingen. Dit levert gegevens die nodig zijn om astronomische waarnemingen te interpreteren en de reactienetwerken in de ruimte te modelleren.

Promotor: Prof.dr. E. Bouwman

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

The adsorption of D2 and CO2 on catalyst surfaces is studied using a molecular beam in ultra-high vacuum.

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

Peptiden worden routinematig gesynthetiseerd in het bereik van 5-80 aminozuren, in een hoeveelheid van 1-200 µmol (kleinere en grotere hoeveelheden zijn ook mogelijk).

De GMP-faciliteit maaktde ontwikkeling en productie van Advanced Therapy Medicinal Products (ATMP's) en chemische (peptide) synthese mogelijk.

This thesis describes research aimed at discovering inhibitors selective for either of the two endoplasmic reticulum α-glucosidases, ER-I and ER-II, with the overarching goal of discovering new antiviral agents to treat viruses that rely on host N-glycosylation for proliferation.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

O-Nitrobenzyl groepen worden veel gebruikt als moleculaire beschermgroepen die je met licht kunt verwijderen.

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

The electrochemical hydrogenation reaction is an alternative approach for the transformation of unsaturated bonds without the use of flammable dihydrogen gas.

This thesis highlights the significant role of surface geometry and oxidation state in determining CO adsorption behavior on copper surfaces.

Kunnen kleine moleculen het immuunsysteem herstellen en helpen tuberculose te bestrijden door autofagie te stimuleren?

LST biedt een uniek onderwijsprogramma dat zich richt op de levende cel. De bacheloropleiding duurt drie jaar. Tijdens je eerste jaar werk je aan een stevig fundament. Daarna is er meer ruimte voor specialisatie.

Hoe gebruiken ziekteverwekkende mycobacteriën de vetten in onze cellen, en hoe kunnen we dat tegenhouden?

Kunnen suikerpatronen op cellen het immuunsysteem activeren om kanker te bestrijden? Sander van Kasteren gebruikt de beurs van de European Research Council (ERC) om te ontdekken of dit mogelijk is.

In 2050 moet de overstap naar nieuwe, duurzame energiebronnen zijn voltooid. Wetenschappers van de Universiteit Leiden verrichten vanuit diverse disciplines uniek onderzoek dat bijdraagt aan deze transitie en de reductie van CO2.

Planten zou je kunnen zien als kleine chemische fabrieken, die via fotosynthese chemische stoffen produceren. Als we fotosynthese kunnen nabootsen in een kunstmatig systeem, kunnen we schone brandstoffen en materialen maken uit zonlicht en CO2. Huub de Groot is heel dicht bij het ontwerpen van zo’n…

On 28 September, the Medieval Murder Maps website will be shared publicly for the first time. The makers have used fourteenth-century coroners' rolls to map the homicides in three medieval towns: London, York, and Oxford. These digital maps are interactive and come with podcasts of interesting cases,…

Ziekteverwekkende bacteriën zijn steeds vaker resistent voor de huidige antibiotica. De vraag naar nieuwe antibiotica wordt daarmee steeds groter. Professor Gilles van Wezel zoekt naar nieuwe vormen van antibiotica in goede bacteriën die in de grond leven.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Dissociative chemisorption is an important reaction step in many catalytic reactions.

The goal of this thesis is to understand how interfacial parameters, such as the addition of organic additives, bulk pH or metal cations of the electrolyte, affect the relevant electrocatalytic reactions, i.e. electrochemical CO2 reduction reaction or hydrogen evolution reaction.