This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

In 2014 ontving Hans-Martien ten Napel een Research Fellowship in Legal Studies aan het Center of Theological Inquiry in Princeton, NJ. Het boek dat hij schreef als uitvloeisel van dit fellowship is vorige week verschenen bij Routledge Law.

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

The aim of the research described in this thesis was to use structure-based design to optimise multiple properties of aryl sulfoxide monoacylglycerol lipase inhibitors as anti-inflammatory analgesics.

Naar schatting bestaat de wereldbevolking over twintig jaar uit ongeveer 8,7 miljard mensen, terwijl dat aantal nu 7,3 miljard is. Deze groei, gecombineerd met de bijbehorende groei in consumptie en de verbeteringen in levensstandaarden, zal resulteren in een enorme groei in de vraag naar voedsel, verbruiksgoederen,…

Design and synthesis of two 3-substituted swainsonine derivatives with the aim to improve the potency and selectivity towards Golgi alpha-mannosidase II.

The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.

Het chemische biologie-onderzoek bij het Leids Instituut voor Chemisch Onderzoek (LIC) is gericht op het begrijpen van biologische processen op moleculair niveau, om zo onze kennis te vergroten over gezondheid en ziekte van de mens.

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

Hoe kunnen we op een interdisciplinaire wijze de classificatie van migranten en mensen met een beperking bestuderen en onderzoekers van deze velden samenbrengen om raakvlakken met elkaar te vinden?

Kunst en vrije tijd, Kunst en vrije tijd

Studievoorlichting, On Campus Experience

Studievoorlichting, On Campus Experience

De prijs wordt elke twee jaar op 10 december (Dag van de Rechten van de Mens) uitgereikt en geldt als erkenning voor wetenschappelijk werk op het gebied van internationale mensenrechten.

Vrijdag 12 januari 2018 zijn de jaarlijkse Meijersprijzen uitgereikt voor het beste gepubliceerde artikel, per facultair onderzoeksprogramma, van onderzoekers in de pre-promotiefase. De winnaars ontvingen een certificaat en een geldbedrag om te besteden aan hun onderzoek.

Adrian Hamers bestudeert de manier waarop hemellichamen om elkaar heen draaien, nu en in de toekomst. Dat blijkt er vaak grilliger aan toe te gaan dan je zou denken. Promotie op 21 juni.

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Promotor: Prof.dr. E. Bouwman

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

Bezuinigen en beboeten: dat is wat het nieuwe kabinet voorstelt. Dat het desastreuze gevolgen gaat hebben vereist geen academisch onderzoek. Het belang van ons onderzoek, en de essentiele bijdragen die Leiden al eeuwen levert aan de Nederlandse samenleving verdienen een spotlight in de politieke waan…

The adsorption of D2 and CO2 on catalyst surfaces is studied using a molecular beam in ultra-high vacuum.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram

Promotor: A. Doelman, Co-promotor: M.F.E. de Jeu

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

This thesis consists of three chapters. Each chapter is on a different subject. However, all three chapters address issues that arise in counting arithmetically interesting objects.

Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Promotie

Promotie

Panel Discussion

Debat, Academic Roundtable

Urbanisation is steadily increasing with estimates expecting that 68% of the global population will live in cities by 2050. To accommodate the rural to urban transition, large quantities of land are transformed from natural to urban lands.

Vrijdag 28 oktober 2016 vond op de Raad van State het symposium ‘De gevolgen van privatisering en liberalisering voor de rechtsbescherming door de bestuursrechter’ plaats. De Afdeling Staats- en bestuursrecht van de Universiteit Leiden en de Raad van State organiseerden gezamenlijk dit symposium, ter…