Agrobacterium-mediated transformation (AMT) has abundantly been used for scientific research for identifying valuable traits.

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

The dissertation offers new tools and insights to computation and modelling of topological phases, with an emphasis on the aperiodic setting.

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

Promotores: Prof.dr. J. Schaye & Prof.dr. C. Steidel (California Institute of Technology)

Op 20 oktober 2021 verdedigde Michael Ramsden het proefschrift 'The Role of the United Nations General Assembly in Advancing Accountability for Atrocity Crimes: Legal Powers and Effects'. Het promotieonderzoek is begeleid door promotor prof.dr. N.M. Blokker.

Promotores: H.W. Lenstra, B. Erez, Co-promotor: L. Taelman

Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

The thesis deals with the study of giant radio galaxies (GRGs), which are radio galaxies of megaparsec sizes.

This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

The interest of this thesis lies in spin transport in normal metals and superconducting half-metallic junctions.

Social event

Security is key to survival for any living organism: life is full of perils and threats, both physically, environmentally, and societally. Security challenges such as terrorism, natural disasters, and cybercrime rank among the most pressing issues of our time, affecting the security and safety of millions…

Van onderwijs tot een verrijkende ervaring

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Het belangrijkste doel van dit onderzoek is om de steden van het Romeinse Nabije Oosten in de keizertijd in kaart te brengen, met een focus op locatie, stadsgrootte en stedelijke kenmerken, om de vorm van het stedelijke systeem en de niveaus van integratie te bestuderen.

Corruption, integrity (or a lack thereof…) and public values are near omnipresent elements in public administration and politics of all times. Cases of corrupt public officials and politicians continuously emerge. Strangely enough, however, it often remains unknown what actually occurred, how something…

The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…

Kunst en vrije tijd, Kunst en vrije tijd

Studievoorlichting

Op 7 december won Marlisa den Hartog de Volkskrant-IISG Scriptieprijs voor Geschiedenis. De titel van haar bekroonde werkstuk luidt ‘The Pleasure that is Taken in Bed: Perceptions of Sexual Desire and Sexual Identity in Italy, 1450-1500’. De scriptie van de laureate werd uit 37 inzendingen gekozen.

Promotores: C.A.J. Knibbe, D. Tibboel, Co-Promotor: P. Bruins

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

IoT technology poses serval opportunities to supply chains. This thesis employs grey correlation and forecasting models, system dynamics, agent-based modeling, and ex-ante LCA to investigate and quantify the opportunities and risks of IoT-enabled sustainable supply chain operations from both industrial…

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Promotor: A. Achúcarro, Co-Promotor: G.A. Palma

There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…

The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

This thesis advances automata learning, a key area in computer science, with applications in software verification, biological analysis, and autonomous technologies. It explores three main themes: first, it introduces a passive learning algorithm for generating compact probabilistic models from positive…

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.

Promotor: H.W. Lenstra

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

Promotor: Prof.dr. P. Stevenhagen, Jan-Hendrik Evertse, Co-promotor: Pascal Autissier

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Transport inspectorates are looking for novel methods to identify dangerous behavior, ultimately to reduce risks associated to the movements of people and goods. We explore a data-driven approach to arrive at smart inspections of vehicles.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

This dissertation is part of a broader research project that revolves around unraveling the evolution of balanced lethal systems.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.