1,587 zoekresultaten voor “academic in marion” in de Publieke website
- Governance
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The flux and flow of data: connecting large datasets with machine learning in a drug discovery envirionment
This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…
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Adjuvanted nanoparticulate seasonal influenza vaccines
Promotor: W. Jiskoot, Co-promotor: A. Kros
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Innovative sample preparation and handling strategies for automated and high-throughput metabolomics
Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…
- Onderzoeksfaciliteiten
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Acquired resistance in pancreatic cancer: characterization and exploration of actionable targets of a multifactorial disease
Promotie
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Eerdere expertisemiddagen
Op deze pagina een overzicht van de programma's van de eerdere expertisemiddagen.
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Psychologieprijzen 2020
De Onderwijsprijs Psychologie is voor alle docenten die online onderwijs mogelijk hebben gemaakt in tijden van corona. Wouter van Loon en Hilmar Zech ontvangen allebei een promovendiprijs. De masterscriptieprijzen zijn voor Robert-Jan de Rooij en Florian Thomas-Odenthal. Marion Duijsman verdient de…
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AFITE
Het fundamentele recht op ‘vrijheid van de kunsten en het wetenschappelijk onderzoek’ in de EU: een verkenning van de grenzen van de commercialisering van de academie (AFITE).
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Universiteit Leiden wint vijf prijzen op IBA ICC Moot Court Competition
Het team uit Leiden heeft vijf prijzen gewonnen op de tiende editie van de IBA International Criminal Court (ICC) Moot Court Competition – English edition 2023, waaronder de prijs voor het beste regionale team uit Europa.
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Open Science Coffee: ChatGPT in science: academic (dis)honesty or better science?
Lezing
- Zelfregulerend leren
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Samenwerken voor efficiënte medicijnontwikkeling
De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap, tot klinische tests, tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…
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Eregalerij 2025
In 2025 hebben medewerkers en studenten van de Universiteit Leiden veel mooie prijzen ontvangen en belangrijke onderzoekssubsidies binnengehaald.
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Van Constantijntje tot Tonio: het dode kind in de Nederlandse literatuur
Het is een van de aangrijpendste literaire genres: ‘dodekindliteratuur’. De Leidse letterkundigen Rick Honings, Olga van Marion en Tim Vergeer stelden het eerste overzichtswerk samen over dit thema in de Nederlandstalige literatuur. De schuldvraag en de rol van God komen vaak terug. ‘Is God een krok…
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Wie is de beste docent?
Het Leids Universitair Studentenplatform (LUS) kiest jaarlijks de beste docent van de universiteit. De prijs wordt uitgereikt tijdens de Opening academisch jaar op vijf september.
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Esmée Driessen benoemd tot lid referendumcommissie Amsterdam
Op 6 november 2019 heeft de gemeenteraad van Amsterdam ingestemd met de benoeming van Esmée Driessen (UL) en Marion Veerbeek (VNG) als nieuwe leden van de Referendumcommissie Amsterdam.
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Podcast: hoe Rembrandt zijn stem terugkreeg
Kunstschilder Rembrandt van Rijn leefde lang voor de uitvinding van geluidsopnames en videocamera’s. Toch is het een groep wetenschappers gelukt om zijn stem te reconstrueren. Hoe? Letterkundige Olga van Marion vertelt erover in Enkeltje Wetenschap.
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Security Studies
Security is key to survival for any living organism: life is full of perils and threats, both physically, environmentally, and societally. Security challenges such as terrorism, natural disasters, and cybercrime rank among the most pressing issues of our time, affecting the security and safety of millions…
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Onderzoeksomgeving
De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap naar klinische tests tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…
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Het ontstekingsremmende effect van het PRG4-eiwit: reumatoïde artritis verlichten en voorkomen
Kan het eiwit PRG4 helpen om de symptomen van reumatoïde artritis te voorkomen of te verlichten?
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Master Track Public Administration: Economics and Governance
The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…
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Metabolomics Faciliteit
We leveren fenotypische read- outs voor diagnose en patiënt stratificatie voor een behandeling op basis van innovatieve metabolomics, UPE en organ-on-a-chip technologie. Met een farmacologische én biologische aanpak bieden we inzicht in ziektemechanismen en vertalen dat voor de gepersonaliseerde gen…
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Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Towards predictive cardiovascular safety: a systems pharmacology approach
Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski
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Towards automated identification of metabolites using mass spectral trees
Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers
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Mast cells in advanced atherosclerosis: from human plaque stability to new therapeutic targets
In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.
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Single-electrolyte isotachophoresis: on-chip analyte focusing and separation
Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Comorbidities, complications and treatment of childhood obesity
Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Dynamics of the renin-angiotensin aldosterone system in dogs: circadian variations in physiological conditions and in relation to angiotensin-converting
Promotor: Prof.dr. M. Danhof
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Supercritical carbon dioxide spray drying for the production of stable dried protein formulations
Promotor: W. Jiskoot, Co-promotor: H.A. Every
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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Modelling the role of cytotoxic T lymphocytes in tumour regression
Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Kennisexploratie en datamining uit ervaringsrepositories van patiënten
Dit project ontwikkelt een wetenschappelijke methode om klinisch relevante nieuwe informatie te extraheren uit patiëntenforum-websites die ervaringen van patiënten bespreken over bv. medicatie, voeding, co-morbiditeiten, genetische factoren enz.
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Unraveling the drivers of antimicrobial pharmacokinetic variability in individuals with obesity and hospitalized patients with multimorbidity
Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.
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Unraveling multifaceted roles of Grainyhead-like transcription factor-2 in breast cancer
Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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Computational modeling of cellular dynamics in tumor cell migration
Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.
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Metabolomics assisted with stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease
The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.