Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotor: Prof.dr. B. van de Water

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Promotores: J. Jonkers, K.E. de Visser

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Promotor: S.M. Verduyn Lunel

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

De LUMC Alumni Vereniging is in 1996 opgericht om enerzijds de band tussen het Leids Universitair Medisch Centrum en zijn alumni te versterken, anderzijds om de band van de alumni onderling te versterken.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Preterm birth is a major contributor to neonatal morbidity and mortality and is associated with both acute complications and long-term health consequences.

Geert Wilders heeft een nieuw plan: mannelijke asielzoekers opsluiten. Discriminerend, oordeelt Rikki Holtmaat.

Carlotta Rigotti, postdoctoraal onderzoeker bij eLaw – Centrum voor Recht en Digitale Technologie, nam deel aan de Artificial Intelligence and Labour Market (AI&LM) Workshop, georganiseerd door de Universiteit Gent, om onderzoeksresultaten uit het BIAS-project te presenteren.

Carlotta Rigotti, postdoctoraal onderzoeker bij eLaw – Centrum voor Recht en Digitale Technologie, en professor Clare McGlynn van Durham University hebben samen een nieuw artikel gepubliceerd in Netherlands Quarterly of Human Rights, getiteld 'Online and technology-facilitated violence against women:…

Met de openstelling van het huwelijk voor partners van gelijk geslacht in 2001 liep Nederland voorop. Toen Kees Waaldijk in 1987 als eerste een artikel schreef over de juridische mogelijkheden daartoe, had hij niet verwacht dat het zó snel zou gaan, zegt de Leidse hoogleraar Comparative Sexual Orientation…

Het voornaamste doel van het Leiden University Diversity and Equality Network (LUDEN) is om een inclusievere werk- en leeromgeving te bevorderen.

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In april 2001 was Nederland het eerste land ter wereld dat het huwelijk openstelde voor paren van gelijk geslacht. Het afstammingsrecht maakt echter nog steeds onderscheid tussen gelijk en verschillend geslacht. Volgens Kees Waaldijk kan dat anders.

Naar aanleiding van onderzoek van de Fundemental Rights Agency van de EU wordt Rodrigues gevraagd waarom moslimdiscriminatie in Nederland opvallend hoger is dan in de meeste andere EU-lidstaten.

Donderdag 23 januari 2020 nam docent en onderzoeker Erwin Dijkstra deel aan een rondetafelgesprek, dat was georganiseerd door het College voor de Rechten van de Mens in het kader van een adviesronde met betrekking tot de positie van (jong)gehandicapten in Nederland.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).