933 zoekresultaten voor “genon verouderen” in de Publieke website
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Imaging of alkyne-functionalized ruthenium complexes for photoactivated chemotherapy
In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.
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Extremely loud & incredibly far: observing radio bright AGN into the cosmic dawn
In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…
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CollegezalengebouwEinsteinweg 57, Leiden
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Piepkleine, pijnvrije vaccinaties: micronaalden en nanodeeltjes
Als het aan promovendus Guangsheng Du ligt, hoeven patiënten niet meer bang te zijn voor dokters met grote naalden. De onderzoeker van het Leiden Academic Centre for Drug Research onderzocht het gebruik van micronaaldjes en nanodeeltjes als nieuw systeem voor vaccinatie. ‘Ik wil een methode ontwikkelen…
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Artikelprijs voor psycholoog Andreas Burger
Tijdens de jaarlijkse bijeenkomst van de onderzoeksschool voor Experimentele Psychopathologie heeft Andreas Burger (Klinische psychologie) de prijs gewonnen voor het beste artikel van 2017.
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Daný van DamFaculteit der Geesteswetenschappen
h.d.j.van.dam@hum.leidenuniv.nl | 071 5272727
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Lesmateriaal
Aan de hand van het lesmateriaal van het Wetenschapsknooppunt Leiden leren de kinderen over wetenschap en onderzoek doen.
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Hoge leeftijd, jong DNA
Sommige mensen van hoge leeftijd blijken DNA te hebben waarvan de afstelling nauwelijks verouderd is. Dat schrijven onderzoekers onder leiding van Bas Heijmans van het LUMC in het wetenschappelijke tijdschrift Genome Biology.
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Arbeidsmarkt
Met een diploma Film- en literatuurwetenschap ben je klaar voor een vliegende start op de arbeidsmarkt. Naast jouw inhoudelijke expertise beschik je na je opleiding namelijk ook over vaardigheden die gewild zijn bij werkgevers. Wil je schrijven of onderzoeken? Werken in de cultuursector of bij de overheid?…
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Het werkende leven in beeld
Je hebt je diploma binnen! Klaar om aan het werk te gaan. Waar kom je terecht?
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Who gets what, when, and how? An analysis of stakeholder interests and conflicts in and around Big Science
Big Science, commonly defined as conventional science made big in three dimensions, namely organizations, machines, and politics, brings a plethora of different stakeholders together, often for a long period of time. This includes policymakers, scientists, (scientific) managers as well as local “host”…
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The integration of meta-analysis and classification & regression trees: meta-CART
In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Crossed product algebras associated with topological dynamical systems
Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov
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On some classes of modules and their endomorphism rings
Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)
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Nuclear magnetic resonance force microscopy at millikelvin temperatures
Promotor: T.H. Oosterkamp
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P. J. Cosijn Research Fellowship
Het P.J. Cosijn Research Fellowship is een initiatief om veelbelovende Research MA-studenten van de Universiteit Leiden met interesse in Angelsaksische studies de kans te geven onderzoek te doen naar Oudengelse taal- en letterkunde. De Cosijn Fellowships zijn onderdeel van het door ERC gefinancierde…
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Chemical biology studies on retaining exo-β-glucosidases
The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).
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Concurrence in European Private Law
Op 9 september 2020 verdedigde Ruben de Graaff zijn proefschrift 'Concurrence in European Private Law'. Het promotieonderzoek is begeleid door promotoren prof.mr. A.G. Castermans en prof.mr. S.C.G. Van den Bogaert.
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Strongly interacting electrons in Sachdev-Ye-Kitaev models and twisted bilayer graphene
In this thesis, we study systems of electrons in which strong correlations give rise to emergent exotic physics.
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Sizing up protoplanetary disks
This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Structural Properties of Single Server Queueing Systems: Efficient Methods via Lumping and Dynamic Programming
This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.
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Bayesian learning: challenges, limitations and pragmatics
This dissertation is about Bayesian learning from data. How can humans and computers learn from data?
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
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Towards an effective biodiversity conservation and governance in the Pontocaspian region
Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…
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Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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Connecting dots between natural and artificial Photosynthesis
Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.
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NeCEN
Met de krachtige elektronenmicroscopen van NeCEN bestuderen we afwijkingen aan cellen van bloedvaten bij hart- en vaatziekten, de wisselwerking tussen ziekteverwekkers en gastheren bij infectieziekten, moleculaire processen die kanker veroorzaken, de interactie tussen geneesmiddelen en target-eiwitten.…
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Long-term observation of protein dynamics via thermal-snapshot single-molecule spectroscopy
This dissertation revolves around the design and implementation of novel instrumentation and related measurement techniques, at the single molecule level, for use in biophysical research. Chapter 1 presents an introduction to the field of fluorescence-based single molecule measurements. In particular,…
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Faith in Democracy. Justice, Politics and Transcendence
This book explores the spiritual potential of faith, mysticism and transcendence in answer to the dangers of a mythologised state and the sacro-sanctification of (liberal) democracy and its rule of law.
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Synthesis of chemical tools to study the immune system
This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.
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A cross-sectional study of early language abilities in children with sex chromosome trisomy (XXY, XXX, XYY) aged 1–6 years
Een goede taalontwikkeling is van belang voor de cognitieve en sociale ontwikkeling, om te kunnen communiceren en om te kunnen leren. Als de taalontwikkeling niet verloopt zoals verwacht, kan dit allerlei consequenties hebben. Kinderen met een extra X of Y chromosoom hebben een verhoogd risico op problemen…
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On the 16-rank of class groups of quadratic number fields
Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)
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Harmful Tax Competition in the East African Community
Op 13 januari 2022 verdedigde Pie Habimana het proefschrift 'Harmful Tax Competition in the East African Community'. Het promotieonderzoek is begeleid door prof.dr. H. Vording en prof.dr. S.C.W. Douma (UvA).
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Interacting risk factors for impulse control behaviours in de novo Parkinson's disease
Up to 45% of patients with Parkinson's disease experience impulse control disorders, characterised by a loss of voluntary control over impulses, drives or temptations. This study aimed to investigate whether previously identified genetic and psychiatric risk factors interact towards the development…
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Miniaturized metabolomics methods for enabling the study of biomass- restricted samples
This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.
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Deep learning for tomographic reconstruction with limited data
Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.
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Clues from stellar catastrophes
Promotores: S.F. Portegies Zwart, E. M. Rossi
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Formalism, Realism and Conservatism in Russian Law
Op 18 december 2019 verdedigde Mikhail Antonov zijn proefschrift 'Formalism, Realism and Conservatism in Russian Law'. Het promotieonderzoek is begeleid door promotor prof.dr. W.B. Simons.
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Noonan and LEOPARD syndrome in zebrafish: molecular mechanisms and cardiac development
Promotor: Prof.dr. J. den Hertog
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Casting light on the ƞ Carinae puzzle
Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura
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Tangent fermions: massless fermions on a lattice
In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.
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Principal algebraic actions of the discrete Heisenberg group
Promotor: Prof.dr. W.T.F. den Hollander
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot
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Systemic Accountability of the European Border and Coast Guard
Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel