In dit artikel onderzoekt William Lippert hoe het overdragen van taken aan een uitvoerder van een overeenkomst van conventionele wapenbeheersing in Europa van invloed is op het succes ervan.

Dit artikel beoordeelt de Russische retoriek ten aanzien van Oekraïne door verklaringen van het Russische ministerie van Buitenlandse Zaken te analyseren.

In dit artikel stelt Tom Buitelaar een systematisch kader voor om het effect van individuele kenmerken van vredeshandhavers op het gedrag van grondpersoneel bij VN-vredesoperaties te analyseren.

Hoye stelt dat het fundamentele fundament van Hobbes' Leviathan grootmoedige staatkunde belichaamt, waarin soevereinen natuurlijke rechtvaardigheid nastreven, die zich manifesteert als eminente

In dit artikel onderzoekt Sophie Vériter hoe een kleine staat het veiligheidsbestuur van de EU beïnvloedt.

In dit artikel bespreken Joachim Koops en Christian Patz de uitgebreide beoordeling van de Duitse gereedheid op het gebied van 'Protection of Civilians' (PoC).

Malte Riemann onderzoekt de evolutie van het huurlingenconcept. Hij stelt dat het idee van de huurling in het 19e-eeuwse Europa ontstond.

Tot wel 50% van de mensen met de ziekte van Parkinson ontwikkelt na verloop van tijd cognitieve achteruitgang; deze studie onderzoekt het gebruik van ‘oefeneffecten’ op neuropsychologische tests als een vroege voorspeller van cognitieve achteruitgang.

Optical cavities are useful tools to enhance the interaction between light and matter, which is important to make good quantum emitters. However, it turns out that the cavities themselves (without any quantum emitters) are already interesting objects to study.

The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

This thesis describes research aimed at discovering inhibitors selective for either of the two endoplasmic reticulum α-glucosidases, ER-I and ER-II, with the overarching goal of discovering new antiviral agents to treat viruses that rely on host N-glycosylation for proliferation.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Kunst en cultuur

Binnen het Institute of Security and Global Affairs is het onderzoek georganiseerd rond zeven domeinen:

GTGC, gevestigd op de Campus Den Haag van de Universiteit Leiden, bevindt zich in het hart van een van 's werelds belangrijkste centra voor mondiaal bestuur. Het programma onderhoudt actief contact met vele belangrijke beleidsmakers. Hieronder vindt u meer informatie over onze banden met Global The…

Hoogleraar Terrorisme en Politiek Geweld Bart Schuurman waarschuwt in de media voor een zorgwekkende trend waarbij staten burgers en criminelen inzetten voor ontwrichtende acties in Europa.

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

Promotie

Is het mogelijk om oxytocine reacties bij gezonde personen farmacologisch te conditioneren en de neurale circuits te identificeren die aan deze conditionering ten grondslag liggen?

Vanavond debatteert de Tweede Kamer over levenslange gevangenisstraffen. ISGA criminologe Marieke Liem is rondom dit thema op meerdere plekken in de media te zien en te horen.

Overzicht

Lezing

The goal of this thesis is to understand how interfacial parameters, such as the addition of organic additives, bulk pH or metal cations of the electrolyte, affect the relevant electrocatalytic reactions, i.e. electrochemical CO2 reduction reaction or hydrogen evolution reaction.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

A plasma is an ionized gas with very low electrical resistivity. As such, magnetic field lines are 'frozen in' and move with the fluid. Magnetic field lines that are linked, knotted and tangled, cannot be undone by the fluid motions.

Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

In this PhD study, I aim to deepen our understanding of the influence of major mycorrhizal types, namely arbuscular mycorrhizae (AM) and ectomycorrhizae (EM), on the global soil carbon cycle and their potential distribution changes under future environmental shifts.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

Freshwater biodiversity has been threatened by eutrophication due to excessive nutrients in the environment. Releasing the freshwater species from such pressures requires efforts from industry and manufacturers to avoid emissions to vulnerable and high-risk regions.

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

This thesis contributes to studying primordial cosmology theories and their detectability in future observations.

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

Congres/symposium

Kiemproject: Hoe kunnen metaforen bijdragen aan betere maatschappelijke betrokkenheid bij quantumwetenschap en -technologie, en welke factoren beïnvloeden de acceptatie of weerstand tegen metaforen bij zowel experts als leken?