Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

Promotor: J. Zaanen, Co-Promotor: V. Juricic

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Promotor: Prof.dr. B.R. Katzy

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…

Promotor: Prof.dr. B. van de Water

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

Promotores: G. Persoon, R. Schefold

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Promotor: R. Cramer

Promotor: J. Aarts

Promotor: Bas Edixhoven, Promotor: Qing Liu

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

This collection of papers was compiled in celebration of the remarkable academic career of Professor Wil Roebroeks, who has established himself as one of Europe’s leading figures in Palaeolithic archaeology over the past three decades and founded the Human origins research group at Leiden University…

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

This thesis investigates Open-world Continual Learning (OWCL), a learning paradigm designed for intelligent systems operating in non-stationary environments with persistent exposure to unknown data.

Quantum position verification (QPV) - the subject of this thesis - is a novel way to authenticate unknown nodes in a quantum network without the need to physically meet up.

Preterm birth is a major contributor to neonatal morbidity and mortality and is associated with both acute complications and long-term health consequences.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Het onderzoek van de afdeling Economie is ondergebracht bij meerdere facultaire programma's. Het onderzoek van de afdeling richt zich thans met name op sociaal-economische vraagstukken, rechtseconomie en fiscale economie.

Over the past two centuries, socioeconomic development has improved material living standards but has also intensified environmental pressures, including climate change and biodiversity loss.

Conventional food supplies procured from rural areas are increasingly vulnerable to disruptions caused by extreme weather, geopolitical instability, and logistical bottlenecks.

Nederland is koploper in Europa op het gebied van deeltijdwerkers. Draagt dat bij aan onze arbeidsmarktkrapte? Volgens Olaf van Vliet, hoogleraar economie, ligt dit ingewikkelder: ‘Het gaat om een afweging tussen betaald werk, zorgverantwoordelijkheden, vrijwilligerswerk en vrije tijd.’

Hieronder vind je de antwoorden op een aantal veelgestelde vragen over toelating tot de klinische specialisaties van de Master Psychologie.

De onderzoeksgroep Terrorism and Political Violence van de Universiteit Leiden bestudeert de oorzaken van radicalisering, de tactieken van extremistische groeperingen, en de effectiviteit van anti-terrorismebeleid. We onderzoeken ook de rol van media en de invloed van postkoloniale erfenissen in de…

Leids rechtshistorisch onderwijs

Promotie

Lezing, Event

Deelproject van

Deelproject van “

KPN heeft op 12 maart de zesde editie van de European Cyber Security Perspectives gepubliceerd. Sergei Boeke, onderzoeker aan het Insitute of Security and Global Affairs, heeft hierin een artikel geschreven over Cyber Warfare.

Deelproject van