This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Welke relatie bestaat er tussen verschillende type PLGs en cognitieve differentiatie?

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Promotor: B. van de Water, Co-promotor: E.H.J. Danen

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

Promotor: A.P.IJzerman Co-promotor: A. Bender

During the course of drug discovery translational steps are made.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Cardiovascular diseases are still a major concern for the global health.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

This thesis aims to test in vitro pipelines to rapidly and cost-effectively identify molecular mechanisms that drive adverse outcomes in clinical use.

Promotie

Oratie

Het fundamentele recht op ‘vrijheid van de kunsten en het wetenschappelijk onderzoek’ in de EU: een verkenning van de grenzen van de commercialisering van de academie (AFITE).

De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap, tot klinische tests, tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…

De studie is een veelzijdige, multidisciplinaire opleiding. De pijlers onder de opleiding zijn scheikunde, (cel)biologie, natuurkunde, wiskunde, (bio-)informatica en farmacologie.

Dit boek neemt je mee op een 1000-jarige wereldreis aan de hand van 100 bijzondere oude kaarten.

We leveren fenotypische read- outs voor diagnose en patiënt stratificatie voor een behandeling op basis van innovatieve metabolomics, UPE en organ-on-a-chip technologie. Met een farmacologische én biologische aanpak bieden we inzicht in ziektemechanismen en vertalen dat voor de gepersonaliseerde gen…

Kan het eiwit PRG4 helpen om de symptomen van reumatoïde artritis te voorkomen of te verlichten?

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap naar klinische tests tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…

Security is key to survival for any living organism: life is full of perils and threats, both physically, environmentally, and societally. Security challenges such as terrorism, natural disasters, and cybercrime rank among the most pressing issues of our time, affecting the security and safety of millions…

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: Prof.dr. M. Danhof

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

​Vertelt het verleden ons wie we zijn? Wijst de geschiedenis ons een weg naar de toekomst? Is historisch besef wel nuttig in een samenleving die ingrijpend verandert?

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Het onderzoek binnen dit domein combineert conceptuele en praktische perspectieven op het gebied van het leren en doceren van tweede talen.

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).