The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Machine Learning is becoming a more and more substantial technology for industry.

Creating a framework to assess the sustainability of fish farms which will set sustainability standards and give consumers information about the the sustainability and safety of their seafood.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

Internationale wetenschappelijke consortia zijn steeds belangrijker binnen de wetenschap. Ze staan tegenwoordig vaak centraal bij de aanpak van mondiale vraagstukken op het gebied van gezondheid, milieu en schone energie. Ze kennen echter ook unieke uitdagingen. Om die in kaart te brengen, ontving hoogleraar…

Promotor: M. Ubbink, Co-promotor: G. Siegal

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

LIACS is a partner in the EU Erasmus+ Curriculum Development for the Asian education system. The knowledge available in the field of Data Science and Artificial Intelligence education will be shared and adapted for the Asian market.

Software and AI in Business (S&B) verbindt de domeinen wetenschap, bedrijfsleven en beleid. Wetenschappelijk onderzoek waar we ons in Leiden op richten, bijvoorbeeld op het gebied van kunstmatige intelligentie, belooft onze samenlevingen ten goede te komen. Het vertalen van wetenschap naar positieve…

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Automated Machine Learning (AutoML) is widely used to automatically build a suitable practical Machine Learning (ML) model for an arbitrary real-world problem, reducing the effort of practitioners in the ML development cycle for real-world applications. Optimization is a key part of a typical AutoML…

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Promotor: Prof.dr. T. Hankemeier

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Biopolymer sequencing with graphene edge-based tunnel junctions has the potential to overcome current limitations with the third generation of sequencing based on biological nanopores.

Afgestudeerden van de masterspecialisatie Onderwijs en Opvoeding in een Digitale Wereld aan de Universiteit Leiden zijn goed voorbereid op uiteenlopende functies. Zij kunnen bijvoorbeeld kindertherapeuten adviseren over e-healthtoepassingen, scholen begeleiden bij het gebruik van digitale middelen en…

Studievoorlichting, proefstuderen

Het onderwerp van dit proefschrift is integratie van klinische kennis en kennis van de basisvakken in het medisch onderwijs en de rol die concept maps kunnen spelen in het expliciet maken van deze zogenoemde verticale integratie.

Promotie

In het programma ‘Verder met publiek leiderschap’ werken het Leiden Leadership Centre van de Universiteit Leiden en verschillende publieke organisaties samen om leiderschap goed te onderzoeken en verder te ontwikkelen. Leiderschapsontwikkeling wordt daarmee evidence-based en wetenschappelijk onderzoek…

Deze opleiding biedt de mogelijkheid om sterrenkundig onderzoek te combineren met kennis over ondernemerschap en ervaring in het bedrijfsleven.

Ontdek de cursus diversiteit en inclusie van het Centre for Professional Learning en krijgt inzicht in de essentie en de praktijk ervan. Lees hier meer!

Deze opleiding biedt de mogelijkheid top onderzoek in de wiskunde te combineren met ondernemerschap, technologie management, innovatiebeheer en besluitvorming in het bedrijfsleven.

Deze opleiding biedt de mogelijkheid om top onderzoek te combineren met kennis over ondernemerschap en ervaring in het bedrijfsleven.