The thesis deals with the study of giant radio galaxies (GRGs), which are radio galaxies of megaparsec sizes.

In his dissertation Michiel Hooykaas outlines the results of six empirical research projects focused at biodiversity awareness in the Netherlands, specifically people’s knowledge about animals.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Promotor: B. van de Water

In Duitsland, Amerika en zelfs in Vietnam: overal ter wereld werd de Leidse ontdekking gedeeld van de geboorte van twee planeten. Astronoom Sebastiaan Haffert wist met zijn team voor het eerst meerdere planeten in wording vast te leggen en publiceerde zijn bevindingen in Nature Astronomy. Een unieke…

Op 14 oktober 2021 is het publieksboek uitgekomen. Sindsdien kunnen alle bestanden en links via deze website geraadpleegd worden.

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh

The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…

The confinement of molecular catalysts in metal-organic frameworks has the potential to lead to significant improvements in selectivity, long term activity and catalyst stability.

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Promotor: M. Ubbink, Co-promotor: G. Siegal

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Automated Machine Learning (AutoML) is widely used to automatically build a suitable practical Machine Learning (ML) model for an arbitrary real-world problem, reducing the effort of practitioners in the ML development cycle for real-world applications. Optimization is a key part of a typical AutoML…

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Software development is a complex process. It is important that software products become stable and maintainable assets.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

Zelfredzaamheid en sociale bescherming over de levenscyclus

Exoplanets close in to their host star receive high levels of extreme ultraviolet (EUV) irradiation, capable of heating and ultimately driving the hydrodynamic escape of their atmospheres.

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

The main aim of this project is to reveal and unravel the invisible histories of the UN, transcending the dominant Western perspective to recover the historical agency of Global South actors. The research will investigate how the UN has both facilitated and limited their role in shaping global order…

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

De Faculteit Geneeskunde

ACPA biedt keuzevakken in kunst, muziek en film. Als student van de Universiteit Leiden maar ook als student van de Hogeschool der Kunsten Den Haag(Koninklijk Conservatorium en Koninklijke Academie van Beeldende Kunsten Den Haag) kun je via ACPA deze keuzevakken volgen.

What is the optimal design of sandy solutions for sustainable climate change adaption, from an ecological, biophysical and societal point of view?

In dit interdisciplinaire project worden data science technieken toegepast om de interactie tussen de Universiteit en stad Leiden (Town&Gown) kwalitatief en kwantitatief zichtbaar te maken vanaf 1575. Een van de mogelijke invalshoeken voor vervolgonderzoek is diversiteit, met name vanuit de internationale…