Promotie

Promotie

Ziekenhuisbacteriën die ongevoelig zijn voor antibiotica vormen een groeiend probleem. De Leidse antibiotica-expert Gilles van Wezel gaat samen met collega Michael Richardson en met experts van het LUMC en Naturalis op zoek naar nieuwe antibiotica in het gif van slangen en schorpioenen. Daarvoor krijgt…

Is het mogelijk om ziektes te diagnosticeren met behulp van moleculaire schakelaars? Over die vraag buigt het nieuwe internationale consortium LogicLab zich. Vanuit Leiden zijn scheikundige Sylvestre Bonnet en farmacoloog Thomas Hankemeier betrokken. Het project loopt voor vier jaar en krijgt ruim 3,5…

Voor Molecular Science and Technology is de matchingsactiviteit een verplicht onderdeel van de inschrijving.

Wil jij de beste redenen weten waarom je aan de Universiteit Leiden moet studeren? Of hoe het is om te leven in studentensteden zoals Leiden of Den Haag? Onze studenten vertellen je over hun studie aan de Universiteit Leiden.

Kunstmatige fotosynthese heeft als doel om via chemische processen zonne-energie om te zettn in brandstof. Semi-kunstmatige fotosynthese is een hybride aanpak waarbij chemische maar ook biotechnologische processen worden gebruikt. Wij hebben als doel om een hybride systeem te ontwikkelen met behulp…

Wil jij de beste redenen weten waarom je aan de Universiteit Leiden moet studeren? Of hoe het is om te leven in studentensteden zoals Leiden of Den Haag? Onze studenten vertellen je over hun studie aan de Universiteit Leiden.

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Studievoorlichting

Lezing

Planets are formed in disks of gas and dust around young stars.

Heb je nog vragen over de opleiding MST? Neem dan gerust contact met ons op!

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

Promotor: Prof.dr. A.G.G.M. Tielens

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Studievoorlichting

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

Promotor: M.T.M. Koper, Co-promotor: L. Juurlink

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.