Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

This research focuses on the distribution of chemical elements in protoplanetary disks, the birthplaces of planets. These disks form around young stars and contain gas and dust, from which planets grow. Ice plays a crucial role in planet formation, aiding the clumping of dust particles and influencing…

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

This thesis is about the study of hydrocarbons via infrared spectroscopy.

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Promotor: Prof.dr. E.F. van Dishoeck

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

This dissertation explores new chemical strategies for the synthesis of self-adjuvanting peptide conjugates and immunomodulatory ligands aimed at targeted activation of the immune system.

A key step in the synthesis of oligosaccharides and glycoconjugates is the formation of the glycosidic bond.

Een team met Leidse sterrenkundigen heeft watermoleculen waargenomen die zich met een snelheid van meer dan 200.000 km per uur van een jonge, zonachtige ster af bewegen. Dit is 80 keer zo snel als een kogel uit een AK47-geweer.

Hoe dragen vetten en enzymen in de hersenen bij aan multiple sclerose? In zijn promotieonderzoek combineerde Daan van der Vliet chemie en neurowetenschap om nieuwe inzichten te krijgen in het ontstaan van hersenziekten.

The aim of the research described in this thesis was to use structure-based design to optimise multiple properties of aryl sulfoxide monoacylglycerol lipase inhibitors as anti-inflammatory analgesics.

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

Design and synthesis of two 3-substituted swainsonine derivatives with the aim to improve the potency and selectivity towards Golgi alpha-mannosidase II.

Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

Lezing, Studium Generale

Kunstmatige fotosynthese heeft als doel om via chemische processen zonne-energie om te zettn in brandstof. Semi-kunstmatige fotosynthese is een hybride aanpak waarbij chemische maar ook biotechnologische processen worden gebruikt. Wij hebben als doel om een hybride systeem te ontwikkelen met behulp…

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

“Een partnerschap gebaseerd op water”, zo vatte Gerhard van den Top de relatie tussen Nederland en de Filipijnen samen in de 4e Louwes lezing. Hij benadrukte de cruciale rol van internationale en interculturele samenwerking in het managen van de complexe uitdagingen veroorzaakt door klimaatverandering.…

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

De aarde, de planeet die wij thuis noemen! Dit is de derde planeet vanaf de Zon en staat op 150 miljoen kilometer. Een jaar op de aarde duurt 365 dagen en een dag 24 uur, precies zoals we gewend zijn. De aarde is 12.742 kilometer in doorsnede en weegt maar liefst 5.972 miljard miljard ton.

Om te overleven op aarde heb je drie dingen nodig: een atmosfeer, water en zonlicht.

Met behulp van straling kan de isotopenverhouding van een skelet worden bepaald. Dit geeft informatie over de locatie waar onze voorouders leefden en wat zij consumeerden. Dr. Andrea Waters ontwikkelde een revolutionaire methode, waarmee het voedingspatroon van tienduizenden jaren geleden kan worden…

Boek over bestrijdingsmiddelen en waterkwaliteit

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.