Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding. De Universiteit Leiden stimuleert studenten om na hun bacheloropleiding door te gaan met de masteropleiding.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Voor de omzetting van zonlicht naar brandstof

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

De olympiades zijn jaarlijkse wedstrijden in (exacte) vakken waar alle scholieren in de bovenbouw van havo en vwo aan mee kunnen doen. De Universiteit Leiden werkt mee aan de volgende Olympiades:

Antropoloog Erik de Maaker ontvangt een beurs voor onderzoekssamenwerking tussen India en Nederland voor het project 'Markets, Ethics and Agency.' De subsidie wordt ingezet voor onderzoek naar de toenemende integratie van de hooglanden van Zuid-Azië.

De Leidse sociaal psycholoog Carsten de Dreu is door zijn benoeming als Distinguished Research Fellow verbonden aan de University of Oxford om mee te denken en te werken aan een groot onderzoek naar besmettelijke ziekte.

Ook in 2020 hebben veel van onze medewerkers en studenten mooie prijzen gewonnen en belangrijke onderzoekssubsidies binnengehaald.

This new Casebook features the work of an international, interdisciplinary research group entitled ‘The Joust as Performance: Pas d’armes and Late Medieval Chivalry’.

Digitale voortgangstoetsing als didactische methodiek.

Hij praat snel en enthousiast. Logisch, want Gerard van Westen is als de machinist op een heel snelle trein. Het eindstation: een virtuele mens, bestaand uit algoritmen die voorspellen wat een toegediende stof doet in ons lichaam. De trein is al een heel eind op weg. De farmaceutische industrie is ook…

Betekenisvol scheikundeonderwijs

Kunstmatige fotosynthese heeft als doel om via chemische processen zonne-energie om te zettn in brandstof. Semi-kunstmatige fotosynthese is een hybride aanpak waarbij chemische maar ook biotechnologische processen worden gebruikt. Wij hebben als doel om een hybride systeem te ontwikkelen met behulp…

De Faculteit der Wiskunde en Natuurwetenschappen heeft verschillende studieverenigingen, die zowel studiegerelateerde als sociale activiteiten organiseren voor studenten.

The overall theme of this thesis is to complement the electrochemical data acquired in fuel cell research with in situ X-ray photoelectron spectroscopy (XPS) and soft X-ray absorption spectroscopy (XAS).

Promotor: Prof.dr. M. Ubbink

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

This thesis describes the design, characterization and application of dextran based crosslinked network.

This dissertation presents the synthesis and evaluation of antibody recognition for various capsular polysaccharide (CP) fragments of Staphylococcus aureus (S. aureus).

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

In this thesis, we study different curved single crystals because of the diversity of surface structures across their curvature.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…