A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

This thesis introduces the concept of

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

This thesis comprises the development of reproducible synthesis procedures for two-dimensional materials (composed of boron, nitrogen and carbon) on different metallic surfaces.

This dissertation was to develop effective graphene-based nanofluidic devices by developing scalable fabrication methods and elucidating proton transport mechanisms.

Bij het streven naar democratische vernieuwing gaat het vaak om het ‘Right to Challenge’, waarmee burgers meer zeggenschap krijgen over hun leefomgeving.

Hieronder vind je een overzicht van de publicaties van LAPP.

Het begrijpen van het veranderende landschap van extremisme in de 21e eeuw.

This project uses archaeological, literary and epigraphic evidence to investigate urban development in Roman-period North Africa, compiling this in a GIS-linked database in order to analyse the development of urban settlement spatially over time.

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

Kees Waaldijk heeft zich jarenlang ingezet om de rechten van de internationale homo- en lesbische gemeenschap in kaart te brengen. Hij neemt afscheid van de faculteit op een moment dat die rechten opnieuw onder druk staan. Hoe kijkt hij terug op zijn carrière?

Samuel Jong behaalt de masterscriptieprijs 2016 van het Instituut Politieke Wetenschap. Met ‘Bridging the Gap: Do Ideological Differences Determine Whether Center-Right Parties Cooperate with the Radical Right?’, rondde Jong zijn master Political Science af. Zijn bevindingen, zijn naar het oordeel van…

Lecturer Andrew Gawthorpe of Leiden University discusses in The Conversation the growing influence of far-right activist Laura Loomer in Donald Trump’s administration.

De Afdeling Jeugdrecht van de Universiteit Leiden en Defence for Children nodigen u van harte uit voor de uitreiking van de achtste Jaap Doek Kinderrechtenscriptieprijs. Deze vindt online plaats, op donderdag 10 december van 15.30 tot 17.00 uur.

De Afdeling Jeugdrecht van de Universiteit Leiden en Defence for Children nodigen u van harte uit voor de uitreiking van de negende Jaap Doek Kinderrechtenscriptieprijs. Deze vindt online plaats, op dinsdag 7 december vanaf 15.30 uur (in het Engels).

De onderzoeksgroep van Coen van Hasselt produceerde razendsnel een app waarmee artsen de juiste dosering van veelgebruikte medicijnen voor coronapatiënten kunnen bepalen. Media in binnen- en buitenland berichtten er uitgebreid over.

Kunstmatige fotosynthese heeft als doel om via chemische processen zonne-energie om te zettn in brandstof. Semi-kunstmatige fotosynthese is een hybride aanpak waarbij chemische maar ook biotechnologische processen worden gebruikt. Wij hebben als doel om een hybride systeem te ontwikkelen met behulp…

Promotor: H.J.M. de Groot

Leids onderzoek draagt bij aan de kennis over duurzaamheidsthema’s. Dit is noodzakelijk om aan gezamenlijke oplossingen te werken voor bijvoorbeeld de huidige klimaat- en grondstoffenproblematiek.

Lezing

Promotor: Prof.dr. M. Ubbink

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Promotor: F. Arbab

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

Promotor: P.D. Grünwald

Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.

One of the most important correlation functions in physics, especially in cosmology, is the energy density, which describes how much energy is present at each point in spacetime due to matter fields. A key contribution to the energy density of the primordial universe comes from gravitational waves (GWs),…

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

The unit residue group, to which the present thesis is devoted, is defined using the norm-residue symbol, which Hilbert introduced into algebraic number theory in 1897.

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Many galaxy clusters exhibit bright diffuse radio emission that traces the underlying structure of the intracluster medium (ICM).

Curved single crystals provide variable, but well-defined surface structures.

Promotores: Prof.dr. F.S. de Boer, Prof.dr. J.J.M.M. Rutten (Radboud Universiteit Nijmegen)