This thesis contains results on the arithmetic and geometry of del Pezzo surfaces of degree 1.In Chapter 1 we give the necessary background, assuming the reader is familiar with algebraic geometry.

Curved single crystals provide variable, but well-defined surface structures.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

To meet the rising demand for minerals driven by the global shift to clean energy technologies, ensuring responsible and resilient supply chains is critical. Minerals like cobalt, lithium, and nickel for batteries, neodymium and zinc for wind turbines, and indium for solar panels are essential.

Promotores: F.H.J. Redig, W.T.F. den Hollander

Promotor: E. Bouwman, Co-promotor: S. Bonnet

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

Understanding interactions in quantum many-body systems remains one of the most profound and difficult challenges in condensed matter physics.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

Promotor: Prof.dr. B. van de Water

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

In dit artikel leveren Bert Fraussen en Valérie Pattyn een theoretische bijdrage aan de bestaande literatuur over beleidsadvies door zich te laten inspireren door de nichetheorie.

In de afgelopen drie decennia is er een sterke toename van het aantal denktanks in de meeste westerse democratieën, waarbij zij steeds meer gezien worden als belangrijke spelers in beleidsprocessen. Toch blijft hun precieze bijdrage aan beleidsvorming gecontesteerd.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

In dit artikel onderzoekt Valentina Carraro de relatie tussen overlappende VN-mensenrechteninstellingen, met name de verdragsorganen en de Universal Periodic Review (UPR).

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Op 24 september 2020 verdedigde Bernardo Ribeiro de Almeida zijn proefschrift 'Building land tenure systems: the political, legal, and institutional struggles of Timor-Leste'. Het promotieonderzoek is begeleid door promotor prof.dr. A.W. Bedner.

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Promotie

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

Op donderdag 16 november 2017 heeft Lalin Kovudhikulrungsri haar proefschrift ‘The Right to Travel by Air of Persons with Disabilities’ verdedigd. Haar promotoren zijn Prof.dr. P.M.J. Mendes De Leon en Prof.mr.dr. A.C. Hendriks.

Traditional hypothesis testing requires researchers to set a fixed sample size in advance. After collecting data, the test determines whether to reject the null hypothesis.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

Promotor: Prof.dr. C.W.J. Beenakker

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

In dit artikel onderzoeken Bart Schuurman & Sarah Louise Carthy de verschillen tussen geradicaliseerde individuen en de algemene bevolking.

Promotores: H.W. Lenstra, A. Lucchini

In de zaak Ferreira da Silva e Brito e.a./Estado portugues heeft het Hof van Justitie in het kader van overgang van onderneming expliciet de luchtvaartsector als kapitaalintensieve sector aangewezen. Hoe verhoudt het arrest zich tot het oordeel van het Gerechtshof Amsterdam over de overgang van de passagedivisie…

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

In this thesis, we address two problems concerning the tautological rings of the moduli space of curves.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Ontdek het studentenleven bij de MSc Political Theory: Legitimiteit en Rechtvaardigheid aan Universiteit Leiden: studieverenigingen, activiteiten, academische gemeenschap en wonen in Leiden en Den Haag.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

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