This thesis presents the anharmonic infrared spectra of a series of polycyclic aromatic hydrocarbons. Comparisons and characterizations are made based on high-resolution low-temperature gas-phase experimental spectra.

Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

This dissertation revolves around the design and implementation of novel instrumentation and related measurement techniques, at the single molecule level, for use in biophysical research. Chapter 1 presents an introduction to the field of fluorescence-based single molecule measurements. In particular,…

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

Promotor: Prof.dr. P.C. van Welzen

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Het domein Diversiteit en Inclusie bestaat uit een leergang Diversiteit & Inclusie en een masterclass Inclusieve Communicatie. Daarnaast is het mogelijk een training aan te vragen op maat voor een bedrijf of organisatie, de zogenaamde 'incompany training'. De D&I leergang die bij het Centre for Professional…

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Lezing, LACG Meetings

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Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

How does the management of Elephant Marsh Fishery in Malawi relate to wider contexts of policies, theories and regions? And how can the current management system be adapted to achieve long-term sustainability of the fishery?

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

In dit project wordt onderzocht hoe onderzoek in de leeromgeving (Research Based Learning of RBL) studenten kan stimuleren om zelf onderzoek te gaan doen. Ook wordt gekeken naar het effect van RBL op het vermogen van studenten om kritisch te denken en op hun academische vaardigheden.

This thesis is divided into two parts. In Part I we study metastability properties of queue-based random-access protocols for wireless networks. The network is modeledas a bipartite graph whose edges represent interference constraints. In Part II we study spectra of inhomogeneous Erdős-Rényi random…

In dit artikel presenteren Andrea Bartolucci en Michele Magni een evidence-based onderzoek naar de spontane opname van slachtoffers en de verdeling van patiënten in de onmiddellijke nasleep van de Manchester Arena Bombing.

By drawing on the personal experiences of contributors based in different institutions and countries, the articles in this special issue provide a fairly broad overview of ethics practices and concerns in different localities (though not globally, as we had originally hoped), showing, as one student…

Promotor: Prof.dr. C.U. Keller, Co-promotor: Frans Snik

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.