Promotor: Prof.dr. B. van de Water

Promotor: Prof.dr. B. van de Water

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

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Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

ELS@Leiden onderzoek omvat een breed scala aan empirisch-juridische projecten die worden uitgevoerd op Leiden Law School, vanuit het perspectief van meerdere disciplines en methodes. Hier kan je de publicaties van onze (voormalige) lab members vinden sinds het begin van het Sector Plan.

Wat zijn de gevolgen van maatschappelijke trends zoals vergrijzing, individualisering en internationalisering voor regelgeving en instituties op het terrein van sociale zekerheid, pensioenen en de arbeidsmarkt?

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

Promotores: S.J. Edixhoven, P.Parent

This thesis focuses on addressing four research problems in designing embedded streaming systems.

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Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

CT scanning of skeletal remains can tell us about how strong or weak a persons bones were and we can relate that back to diet, activity, and reproductive factors.

Voor de teksten van dit gidsje is de volgende literatuur gebruikt:

Meedoen aan veldwerk, een lezing bijwonen, meespeuren? Hier vindt u de geplande activiteiten en informatie hoe u deel kunt nemen. Kijk ook op de pagina publicaties om artikelen te lezen, webinars terug te kijken, etc.

De Landelijke Werkgroep Kind en Ouder in de Strafrechtsketen (KOS) heeft als doel de zichtbaarheid en behandeling van ouders en kinderen in de Nederlandse strafrechtsketen te verbeteren door een combinatie van centralisatie, advies en onderzoek.

Dynamical systems describe the evolution of objects in a space over time and may be used to model physical phenomena. Due to this, much research is dedicated to understanding the mathematics of dynamical systems.

Het Expertisebureau D&I werkt nauw samen met de faculteiten van de Universiteit Leiden.

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Het vertrekpunt van dit onderzoek is de bevinding dat het menselijk brein vatbaar is voor allerlei denkfouten en vooringenomenheden (biases), die onze percepties kleuren en onze redenaties beïnvloeden, zonder dat we dit bewust doorhebben. Integendeel, mensen hebben veelal het gevoel dat zij slechts…