Promotor: Prof.dr. A.W. van der Vaart

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Lezing

Voor haar onderzoek trekt promovenda Liselore Tissen langs verschillende Nederlandse musea, waar ze schilderijen inscant om ze later 3D te printen. Het Leidsch Dagblad en Omroep West besteedden aandacht aan haar werk.

This thesis focuses on addressing four research problems in designing embedded streaming systems.

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

Onderzoekers verbonden aan COI@Leiden hebben veel gepubliceerd over een breed scala aan onderwerpen binnen het thema conflictoplossende instituties.

In Nederland bieden ongeveer 130 van de 700 middelbare scholen een tweetalige stroom aan. Toch is er nog maar weinig wetenschappelijk onderzoek naar CLIL (content and language integrated learning). Met haar proefschrift wil Evelyn van Kampen (promovendus bij het ICLON) bijdragen aan een beter begrip…

Congres/symposium

This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.

Webinar, Q&A, discussion

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

Quantum annealing belongs to a family of quantum optimization algorithms designed to solve combinatorial optimization problems using programmable quantum hardware. In this thesis, various methods are developed and tested to understand how to formulate combinatorial optimization problems for quantum…

This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…

Het ERC consolidator project

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

Agrobacterium-mediated transformation (AMT) has abundantly been used for scientific research for identifying valuable traits.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

This dissertation explores how we can make anomaly detection—identifying unusual or faulty behavior in complex systems—more trustworthy and effective, with a focus on smart manufacturing.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Promotor: F.S. de Boer, Co-promotor: M.M. Bonsangue

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Wist je dat je na succesvolle afronding van de minor Boek, boekhandel en uitgeverij de aansluitende masteropleiding kunt volgen? Lees hier meer over de specialisatie Book and Digital Media Studies van de masteropleiding Media Studies (MA).

'Ik ben ervan overtuigd dat als er momenteel nog geen publieke omroep zou bestaan en we zouden bedenken dat het goed zou zijn om publiek geld (oftewel belastinggeld) te steken in journalistiek, het in niemand zou opkomen om dat geld te spenderen aan algemeen nieuws op radio, televisie en internet. Dat…

De opmars van het gebruik van laptops en tablets in het klaslokaal is in volle gang. Maar wat zijn de gevolgen van leren met een scherm? NEMO Kennislink sprak met Adriaan van der Weel, bijzonder hoogleraar in de moderne geschiedenis van het boek.

De Universiteit Leiden heeft op het moment op drie verschillende locaties Kunstmatige Intelligentie (AI) laboratoria: - Het Digital Lab, wat onderdeel is van de Humanities Hub in het Huizinga Gebouw - Het Physical Twin Lab in het Gorlaeus Gebouw - Het Archeologie Lab in the Van Steenis Gebouw

This thesis probes under what conditions quantum computing presents an advantage over classical computing.

Promotor: A.W. van der Vaart

The studies in this thesis are focused on the physical effects in the flat band materials. The results contain the discovery of strong enhancement of RKKY spin-spin interactions with specific geometric arrangement and dynamical generation of excitonic order parameter with high magnitude.

In this thesis, classes of strongly interacting quantum field theories, have been studied.

Make more fluid: In condensed matter systems, electrons can acquire unusual properties from their interaction with the atomic lattice.

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Water is all around us and is vital for all aspects of life. Studying the various compounds and life forms that inhabit natural waters lets us better understand the world around us.