One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Preterm birth is a major contributor to neonatal morbidity and mortality and is associated with both acute complications and long-term health consequences.

MST biedt verschillende voorlichtingsactiviteiten –zowel in Leiden en Delft- om je te helpen bij je studiekeuze.

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

Antibioticaresistentie is een van de grootste bedreigingen wereldwijd voor de volksgezondheid in de komende decennia.

Na de master kiezen de meeste alumni voor een baan in het bedrijfsleven of bij de overheid.

In de AD-rubriek de 'Zomeruniversiteit' vertellen de knapste koppen van Nederland over de ontwikkelingen in hun vakgebied. Deze week was de beurt aan hoogleraar Moleculaire astrofysica Ewine van Dishoeck.

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89 toponderzoekers schreven blogs over onderwerpen waar het in de bèta-wetenschap op dit moment om draait. Op basis van de blogs, onder meer uit Leiden, stelde De Groene Amsterdammer een lijst samen van 10 verwachte doorbraken in de bèta-wetenschappen. Lees de Leidse béta-blogs: Van opgekweekte stamcellen…

Onderwijs omvat wiskunde, informatica en data science, astrofysica, natuurkunde, chemie tot bio-farmaceutische wetenschappen, biologie en milieukunde.

Ze zijn allebei chemicus maar de een bestudeert de onmetelijke ruimte en de ander de kleinste bestanddelen van de menselijke cel. Ewine van Dishoeck, hoogleraar Astrochemie, en Hermen Overkleeft, hoogleraar Bio-organische synthese, kregen beiden een Europese miljoenensubsidie.

Prof. A.G.G.M. (Xander) Tielens wordt bij 1 januari bij de Faculteit der Wiskunde en Natuurwetenschappen benoemd tot hoogleraar ‘Physics and Chemistry of the Interstellar Medium’. Tielens werkt momenteel als senior onderzoeker bij Ames in Moffett Field, Californië. Ames is een onderdeel van NASA. Daarnaast…

Complexe moleculen, waaronder de bouwstenen van het leven, ontstaan in laagjes ijs op ultrakoude stofdeeltjes (-260 oC) in de ijle ruimte tussen en rondom sterren. Om deze processen goed te begrijpen gaan Leidse sterrenkundigen een unieke opstelling ‘CRYOPAD’ voorzien van nieuwe en betere meetapparatuur.…

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Het Natuurwetenschappelijk Gezelschap Leiden heeft haar succes mede te danken aan de diverse besturen die de lezingen, vergaderingen en activiteiten van het gezelschap hebben verzorgd.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Promotor: Prof.dr. H.S. Overkleeft

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Promotor: A.P. IJzerman

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Promotor: A.P. IJzerman

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Leiden en Delft zijn zeer geschikt om de MST te combineren met persoonlijke ontwikkeling en te werken aan jouw toekomst.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang