The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

This thesis investigates Open-world Continual Learning (OWCL), a learning paradigm designed for intelligent systems operating in non-stationary environments with persistent exposure to unknown data.

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

The LUGO Press is a student publication forum, rooted in academia and journalistic practices and published by the Leiden University Green Office.

This thesis describes research aimed at discovering inhibitors selective for either of the two endoplasmic reticulum α-glucosidases, ER-I and ER-II, with the overarching goal of discovering new antiviral agents to treat viruses that rely on host N-glycosylation for proliferation.

The basic program comprises a total of twelve courses organized by the Research School, that have been purpose-developed for training and support of PhD students and Research MA students who specialize in Medieval Studies (history, art history, and literary history, in particular).

In this dissertation (titled: Exploring the Synergies between Transfer in Reinforcement Learning and Procedural Content Generation) we explore how the two research fields named in the title, namely Transfer in Reinforcement Learning (TRL) and Procedural Content Generation (PCG) can synergize togethe…

Kijk regelmatig op deze pagina voor meer informatie over het vergroten van de biodiversiteit aan de Universiteit Leiden.

Are you planning to conduct clinical research in the Netherlands? In this online course, you are introduced to legislation and procedures on clinical research in the Netherlands. It will help you prepare and submit your research file efficiently. The first three themes ‘The Dutch Review System’ , ‘The…

In this thesis we push the boundaries of high-resolution imaging at radio frequencies between 100 and 200 MHz. Using the International LOFAR Telescope that spans across Europe we achieve sub-arcsecond angular resolution.

Promotor: H.W. Lenstra

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

Promotor: G.J.B. van Ommen

In this top-rated course, you will learn how the European Union prepares and decides on policy, and how policy is transferred to member states and implemented by various authorities. It discusses the challenges of the European multi-level governance structure and the main causes of policy failure or…

In this course, we will focus on the fascinating history of the Arabic Medieval World. We will take you on a journey through the Middle Ages. All along, we will present you with historiographical debates and dilemmas and travel back and forth in time explaining to you how events of the past affected…

Promotie

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Promotor: Prof.dr. M. Schilthuizen

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

In this project of the Center for Public Values & Ethics (CPVE) ongoing research is conducted on the history of advice to Dutch central government by so-called State committees from 1814 to 2014. State committees have been installed by Dutch central government since 1814 to provide expert advice, research…

In het academisch jaar 2023-2024 biedt het interdisciplinaire onderzoeksprogramma Sociale Veerkracht en Veiligheid vier vakken aan voor studenten die beginnen met het derde jaar van hun bachelor. Deze vakken zijn te volgen binnen de ruimte voor keuzevakken. Je kunt de vakken afzonderlijk als keuzevak…

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

Our recent excavations have focused on the more recent New Kingdom/Late Period (ca. 1500-332 BCE) material.

Announcement of a new publication by Janneke Verheijen, lecturer at the Institute of Cultural Anthropology and Development Sociology.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotores: H.W. Lenstra, A. Lucchini

Agrobacterium-mediated transformation (AMT) has abundantly been used for scientific research for identifying valuable traits.

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

PhDArts co-director Dr. Janneke Wesseling’s e-book ‘De volmaakte beschouwer, De ervaring van het kunstwerk en receptie-esthetica’ was recently published. The key question of the book is: how does the work of art work?

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh

De afdeling Bedrijfswetenschappen houdt zich bezig met vraagstukken op het gebied van ondernemerschap, organisatiepsychologie en insolventie. Op de afdeling werken docenten en onderzoekers uit verschillende disciplines, zoals marketing, economie, finance, strategie en de gedragswetenschappen.

Although plant domestication has significantly altered crop genetics and phenotypes, its effects on the taxonomic and functional diversity of plant-associated microbiomes are not well understood.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

Op 20 oktober 2021 verdedigde Michael Ramsden het proefschrift 'The Role of the United Nations General Assembly in Advancing Accountability for Atrocity Crimes: Legal Powers and Effects'. Het promotieonderzoek is begeleid door promotor prof.dr. N.M. Blokker.

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.