The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

Promotor: H.V.J. Linnartz

Promotor: A.P. IJzerman

Promotor: B.van de Water, Co-promotor: L.S.Price

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.

Promotor: Prof.dr. M. de Jong

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

Promotores: P.G.L. Klinkhamer, P.M. Brakefield, Co-Promotor: M. Bruinsma

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

This thesis addresses the challenge of sustainable urban development by analyzing the interplay between green and grey infrastructure to optimize resource use and ecosystem services.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Environmental challenges such as plastic pollution and biodiversity loss require extensive monitoring. Citizen science, in which members of the public participate in scientific research, has therefore become an important approach in environmental science.

Quantum position verification (QPV) - the subject of this thesis - is a novel way to authenticate unknown nodes in a quantum network without the need to physically meet up.

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Overzicht

Wil je graag iets doen voor de slachtoffers van de oorlog in Oekraïne? Er zijn verschillende acties opgezet om mensen in Oekraïne te helpen. Lees hier onder wat jij kunt doen.

De agenda voor Vrouwen, Vrede en Veiligheid (WPS), die voortkomt uit Resolutie 1325 van de Veiligheidsraad van de Verenigde Naties, heeft een kritiek moment bereikt in haar korte twintigjarige geschiedenis. Ondanks dat het tien resoluties omvat die bedoeld zijn om de agenda te versterken en de reikwijdte…

Het Expertisebureau Diversiteit en Inclusie staat in nauw contact met verschillende studenten- en medewerkersnetwerken op het gebied van diversiteit en inclusie.

En dan ben je afgestudeerd historicus. Je kennis van het verleden geeft een stevige basis voor de toekomst. Bovendien ben je een onafhankelijke, kritische denker en onderzoeker. Dat maakt je geschikt voor veel verschillende functies.

Lezing, Sociolinguistics & Discourse Studies Series

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Promotor: Peter Stevenhagen

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Het Instituut Politieke Wetenschap is een levendige, diverse gemeenschap met een wetenschappelijke staf van circa 70 onderzoekers. Het Instituut is gehuisvest in Leiden en Den Haag.

Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich