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2,142 zoekresultaten voor “strw cell differentiatie” in de Publieke website

• Macrophage cell models for the investigation of Gaucher disease Agenda - 6 januari 2026

  Promotie

• T-cell gene therapy for low mutational burden cancer Agenda - 9 januari 2025

  Promotie

• Primary T-cell responses against SARS-CoV-2 in hematological patients Agenda - 12 februari 2026

  Promotie

• Ziekten genezen met organen uit het lab Nieuws - 15 november 2022

  Organen en weefsels uit het lab kunnen in de toekomst mensen met orgaanfalen genezen. Micha Drukker is ervan overtuigd dat dit dankzij stamcellen werkelijkheid wordt. Op 18 november houdt de hoogleraar Stem Cells, Developmental Biology and Technology for Innovative Drug Research zijn oratie.

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  Ferdinand Teichert Promovendus / gast

  Faculteit der Wiskunde en Natuurwetenschappen

  f.m.a.teichert@lacdr.leidenuniv.nl | 071 5272727

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  Max Fernkorn Onderzoeker

  Faculteit der Wiskunde en Natuurwetenschappen

  m.fernkorn@lacdr.leidenuniv.nl | 071 5272727

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  Micha Drukker Hoogleraar

  Faculteit der Wiskunde en Natuurwetenschappen

  m.drukker@lacdr.leidenuniv.nl | 071 5276271

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  Andreea Iosif Analist

  Faculteit der Wiskunde en Natuurwetenschappen

  c.a.iosif@lacdr.leidenuniv.nl | 071 5276302

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  Ruben de Vries Promovendus

  Faculteit der Wiskunde en Natuurwetenschappen

  r.j.de.vries@lacdr.leidenuniv.nl | 071 5276228

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  Cecile Herbermann Project analist

  Faculteit der Wiskunde en Natuurwetenschappen

  c.j.herbermann@lacdr.leidenuniv.nl | 071 5272727

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  Rafaella Buzatu Promovendus

  Faculteit der Wiskunde en Natuurwetenschappen

  r.buzatu@lacdr.leidenuniv.nl | 071 5276227

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  Eliane Züger Promovendus

  Faculteit der Wiskunde en Natuurwetenschappen

  e.a.k.zuger@lacdr.leidenuniv.nl | 071 5276227

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  Daan Vlemmings Analist

  Faculteit der Wiskunde en Natuurwetenschappen

  d.m.j.vlemmings@lacdr.leidenuniv.nl | 071 5276302

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  Yubin Guo Promovendus / gast

  Faculteit der Wiskunde en Natuurwetenschappen

  y.guo.11@lacdr.leidenuniv.nl | 071 5276227

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  Benjamin Tak Promovendus

  Faculteit der Wiskunde en Natuurwetenschappen

  b.l.t.tak@lacdr.leidenuniv.nl | 071 5276228

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  Yuting Wang Promovendus

  Faculteit der Wiskunde en Natuurwetenschappen

  y.t.wang@lacdr.leidenuniv.nl | 071 5272727

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  Joey Zuijdervelt Promovendus

  Faculteit der Wiskunde en Natuurwetenschappen

  j.l.zuijdervelt@lacdr.leidenuniv.nl | 071 5276227

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  Nina Schulten Onderzoeksanalist

  Faculteit der Wiskunde en Natuurwetenschappen

  n.schulten@lacdr.leidenuniv.nl | 071 5272727

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  Jingchao Wu Onderzoeker

  Faculteit der Wiskunde en Natuurwetenschappen

  j.wu@lacdr.leidenuniv.nl | 071 5276227

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  Christian Schröter Universitair docent

  Faculteit der Wiskunde en Natuurwetenschappen

  c.schroter@lacdr.leidenuniv.nl | 071 5272727

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  Rafaël Vos Gast-onderzoeker

  Faculteit der Wiskunde en Natuurwetenschappen

  r.e.vos@lic.leidenuniv.nl | 071 5272727

• Exploring big data approaches in the context of early stage clinical Onderzoeksoutput

  Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

• Activity-based protein profiling in drug discovery Onderzoeksoutput

  In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

• Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice Onderzoeksoutput

  In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

• Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana Onderzoeksoutput

  Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

• Developing systems for high-throughput screening of infectious diseases using zebrafish Onderzoeksoutput

  Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

• Microglial lipid metabolism: a delicate balance Onderzoeksoutput

  Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

• CE-MS for metabolomics: advancing performance and detection sensitivity Onderzoeksoutput

  The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

• Direct and two-step activity-based profiling of proteases and glycosidases Onderzoeksoutput

  Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

• Cancer chess: molecular insights into PARP inhibitor resistance Onderzoeksoutput

  The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

• Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors Onderzoeksoutput

  Promotor: A.P. IJzerman

• Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management Onderzoeksoutput

  The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

• To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors Onderzoeksoutput

  Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

• Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor Onderzoeksoutput

  Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

• Allosteric modulation and ligand binding kinetics at the Kv11.1 channel Onderzoeksoutput

  Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

• Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis Onderzoeksoutput

  This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

• Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors Onderzoeksoutput

  The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

• Piecewise deterministic Markov processes: an analytic approach Onderzoeksoutput

  Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

• The structure of a working catalyst: from flat surfaces to nanoparticles Onderzoeksoutput

  Promotor: Prof.dr. J.W.M. Frenken

• Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands Onderzoeksoutput

  Promotores: A.P. IJzerman, H.W.T. van Vlijmen

• Development of kinase inhibitors and activity-based probes Onderzoeksoutput

  Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

• Lipid bilayers decorated with photosensitive ruthenium complexes Onderzoeksoutput

  Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

• Bioorthogonal tools to study fatty acid uptake in immune cells Onderzoeksoutput

  The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.

• Radio galaxies at low frequencies: high spatial and spectral resolution studies with LOFAR Onderzoeksoutput

  Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

• Spectroscopic characterization of exoplanets: From LOUPE to SINFONI Onderzoeksoutput

  Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

• From intracluster medium dynamics to particle acceleration Onderzoeksoutput

  The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

• A well-established harmony in chaos: from isolated galaxies to galaxy clusters Onderzoeksoutput

  The origin and evolution of galaxies are closely linked to many different physical phenomena.

• The astrochemical factory: A solid base for interstellar reactions Onderzoeksoutput

  In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

• Atom addition reactions in interstellar ice - new pathways towards molecular complexity in space - Onderzoeksoutput

  Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

• Unveiling the third dimension: vertical structure as a probe of planet formation conditions Onderzoeksoutput

  Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…