With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Promotor: Prof.dr. E.F. van Dishoeck

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

In my research, I used a comparative wood anatomical approach to address wood evolution of the (largely) tropical flowering plant families Apocynaceae and Sapotaceae.

Hydrogen fuel cells are expected to be pivotal in the energetic transition towards renewable energy sources such as solar and wind power. However, their industrial scalability is severely hindered by the high cost and degradation rate of platinum catalysts, one of their key components. Addressing this…

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Promotor: S.M. Verduyn Lunel, Co-promotores: M.F.E. de Jeu, B. de Pagter

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

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This collection of papers was compiled in celebration of the remarkable academic career of Professor Wil Roebroeks, who has established himself as one of Europe’s leading figures in Palaeolithic archaeology over the past three decades and founded the Human origins research group at Leiden University…

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Green hydrogen is produced via a process called water electrolysis. During electrolysis water is split into oxygen and hydrogen.

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

Plastics have become an integral part of modern society due to their versatility and durability.

Astronomen van de Sterrewacht Leiden hebben een nieuwe methode ontwikkeld om verre quasars te vinden en beter te onderscheiden van andere objecten die erop lijken, met behulp van technieken voor machinaal leren. Het onderzoeksresultaat is geaccepteerd voor publicatie in het vakblad Astronomy & Astrophysics.…

Het menselijk brein slaat niet alleen losse woorden op, maar ook allerlei abstractie informatie over die woorden. Sprekers hebben daar bovendien actief toegang toe, blijkt uit onderzoek van Leidse taalkundigen.

Op 11 juni 2020 verdedigde Sabine Witting haar proefschrift 'Child Sexual Abuse in the Digital Era: Rethinking Legal Frameworks and Transnational Law Enforcement Collaboration'. Het promotieonderzoek is begeleid door promotoren prof.mr. J.J. Sloth-Nielsen en prof.dr.mr. S. van der Hof.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Agrobacterium-mediated transformation (AMT) has abundantly been used for scientific research for identifying valuable traits.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

Promotores: J. Kok, M. Chaudron (Chalmers University)

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Promotor: Prof.dr. M.A.G.J. Orrit

In his dissertation Michiel Hooykaas outlines the results of six empirical research projects focused at biodiversity awareness in the Netherlands, specifically people’s knowledge about animals.

Dynamical systems describe the evolution of objects in a space over time and may be used to model physical phenomena. Due to this, much research is dedicated to understanding the mathematics of dynamical systems.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

In-use stocks of products can be considered as intermediaries between human needs and the physical world.

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

Promotor: J.W. van Holten