Promotor: Prof.dr.ir. E. Deprettere

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Astronomen willen het heelal begrijpen, van de Oerknal tot nu, en hoe dit verder zal gaan. In Leiden concentreren ze zich daarbij op twee vragen: 'Hoe ontstaan sterren en planeten? en 'Hoe ontstonden in het jonge heelal sterrenstelsels en zwarte gaten?' Een nieuwe generatie telescopen – net klaar of…

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Overlevingsanalyse is een onderzoeksgebied dat zich richt op het bestuderen van de tijd tot het optreden van een specifieke uitkomst.

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

Promotie

Lezing

We consider the propagation of electrical signals through nerve fibres.

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

This dissertation advances automated negotiation by developing agents that can learn and adapt across diverse negotiation settings through three increasingly sophisticated approaches: automated algorithm configuration, portfolio-based strategy selection, and end-to-end reinforcement learning with graph…

This thesis contains results on the arithmetic and geometry of del Pezzo surfaces of degree 1.In Chapter 1 we give the necessary background, assuming the reader is familiar with algebraic geometry.

Former PhD student of the Leiden Institute of Advanced Computer Science (LIACS) Bart Thomee has received this year’s Rising Star Award from the Multimedia group of ACM, the worldwide computer science association. Today, Thomee is a successful researcher at Yahoo Labs.

Welke consumentengroepen hebben de grootste impact op de volksgezondheid en de planeet door hun voedingskeuzes, en hoe kunnen we deze inzichten gebruiken om de transitie naar duurzame eetpatronen te versnellen?

Aan de opleidingen van het Centre for Professional Learning op het gebied van Terrorisme, Recht en Veiligheid zijn verschillende (research) fellows verbonden. De fellows geven advies over de inhoud van het curriculum en de verbinding tussen wetenschap en praktijk.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

In this thesis,

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Promotor: Prof.dr. M. Ubbink

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

This thesis focuses on addressing four research problems in designing embedded streaming systems.

We are living in an information era where the amount of image and video data increases exponentially.

Promotor: Prof.dr. C.W.J. Beenakker

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Promotor: H.J.M. de Groot

Astronomen onder leiding van Simon Portegies Zwart gebruikten simulaties om te reconstrueren hoe drie sterren 60.000 jaar geleden uit de sterrenhoop R136 werden geslingerd. Uit de analyse blijkt dat er vijf sterren betrokken waren bij de gebeurtenis in de Tarantulanevel.

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

Promotores: H. Schiessel, G.T. Barkema

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

Promotie

Promotie

The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…

Het seminar op 30 november jl. over schijnconstructies en intra EU arbeidsmigranten trok veel belangstellenden en was een succes. Deze bijeenkomst werd georganiseerd vanuit het onderzoeksproject Solidarity under Strain (SOLID), onderdeel van de Research Focus Area 'Interaction between Legal Systems…