In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Promotor: H.J.M. de Groot

Discover the master program population Health Management at Leiden University and contribute to a more integrated health care system. Learn more!

The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

Promotores: H. Schiessel, G.T. Barkema

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

Astronomen onder leiding van Simon Portegies Zwart gebruikten simulaties om te reconstrueren hoe drie sterren 60.000 jaar geleden uit de sterrenhoop R136 werden geslingerd. Uit de analyse blijkt dat er vijf sterren betrokken waren bij de gebeurtenis in de Tarantulanevel.

The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…

Promotie

Promotie

Het seminar op 30 november jl. over schijnconstructies en intra EU arbeidsmigranten trok veel belangstellenden en was een succes. Deze bijeenkomst werd georganiseerd vanuit het onderzoeksproject Solidarity under Strain (SOLID), onderdeel van de Research Focus Area 'Interaction between Legal Systems…

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

Twaalf Leidse onderzoekers ontvangen restgelden in het kader van ILS 2.0. Met dit onderzoeksgeld kunnen zij zich richten op het voorbereiden van subsidievoorstellen en het ontwikkelen van nieuwe onderzoekslijnen.

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

Lezing

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Het profileringsgebied Interaction between Legal Systems is multidisciplinair en stimuleert innovatief onderzoek met een inhoudelijke focus op de interactie tussen rechtsstelsels. Voor de komende onderzoeksperiode 2016-2020 zijn uit alle inzendingen drie winnende projecten geselecteerd.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Promotor: W. Jiskoot, Co-promotor: A. Kros

De onderzoeksgroep Business, Technology & Public Policy van de afdeling Bedrijfswetenschappen van Universiteit leiden houdt zich bezig met het onderzoeken van de dynamische wisselwerking tussen ‘nieuwe’ technologieën en de verschillende belanghebbenden die hiermee interacteren, waaronder consumenten,…

Op 21 september gaf Magdalena Jozwiak, onderzoeker bij eLaw - Centrum voor Recht en Digitale Technologie, een presentatie over het e-SIDES project tijdens een ILS Lunch Seminar.

Projecten van de afdeling Environmental Biology

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

Cursus

In this thesis, we examine various systems through the lens of several numerical methods.

Promotores: F.H.J. Redig, W.T.F. den Hollander

Promotores: G.A. Persoon, H.H. de Iongh

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

The global agri-food system plays a critical role in food security and environmental issues.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Onderzoekreeks van de Afdeling Economie van de Universiteit Leiden op het raakvlak van economie en recht.

Op vrijdag 24 februari zal Prof. Judith Masson (Bristol University), Hoogleraar Rechtssociologie en Fellow bij the UK Academy of Social Science, een lezing geven binnen de Leiden Socio-Legal Series.

Op vrijdag 24 maart gaf prof: Amanda Perry-Kessaris (Kent Law School) een korte workshop over data visualisation voor de promovendi van de afdeling Economie. Tijdens deze workshop werden de promovendi uitgedaagd om door middel van LEGO hun onderzoek te visualiseren. Amanda Perry-Kessaris gaf daarna…

In het kader van ILS 2.0 zijn er restgelden beschikbaar voor het indienen van subsidievoorstellen en - direct daaraan gekoppeld en inherent daaraan - het ontwikkelen van nieuwe onderzoekslijnen. Per aanvraag geldt een maximumbudget van 40.000 euro. In totaal is 180.000 euro beschikbaar voor deze cal…

Prof. Tim de Zeeuw is de winnaar van de Brouwer Award 2010, een prijs die jaarlijks wordt uitgereikt door de 'Division on Dynamical Astronomy of the American Astronomical Society'. De prijs bestaat uit $2000 en een certificaat.

In this thesis, classes of strongly interacting quantum field theories, have been studied.

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.