Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: J. Schaye

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

Promotor: W. Jiskoot, Co-promotor: H.A. Every

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotor: Prof.dr. G.P. van Wezel

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Promotor: Prof.dr. H.J.A. Rottgering

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

Make use of this time to improve your language skills by signing up for custom-made online language classes.

The field of science communication is very broad. Below is a list of organisations where SCS students can fulfill internships or where alumni have found jobs.

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

To study how planetary systems come into existence we study much younger systems still in formation.

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Promotor: C.J. ten Cate

Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

We consider the propagation of electrical signals through nerve fibres.

In this thesis, we study systems of electrons in which strong correlations give rise to emergent exotic physics.

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

The following report discusses a survey on the topic of the Sustainable Development Goals that was distributed among researchers at Leiden University in the month of November 2021.

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.

In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Loopbaan en solliciteren

Maar liefst negen Leidse studenten spelen deze maand mee in het grootste projectorkest voor studenten in Nederland, het Nederlands Studenten Orkest. Op donderdag 15 februari spelen ze in de Stadsgehoorzaal in Leiden. Het thema van het concert: DROOM.

Tijdens de Week van de Internationale Student, gehouden van 14 tot en met 18 november, willen we onze internationale studenten in het zonnetje zetten. Ricardo Alexandre de Jesus Vaz (21) uit Portugal is bezig aan zijn eerste jaar bij FGGA als masterstudent International Relations and Diplomacy (MIR…

De Leiden University Excellence Scholarship Programme (LExS) beurzen zijn weer uitgereikt. In 2017 kregen 53 excellente studenten uit 25 verschillende landen een LExS-beurs.

Lezing

Masterstudenten Industriële ecologie en Governance of Sustainability hielpen om duurzaamheidsvraagstukken van bedrijven en overheden te beantwoorden.

'Ik ga afstuderen! Maar wat ga ik nu doen?' Een vraag waarmee jongeren worden geconfronteerd bij de overgang naar een vervolgopleiding of aan het begin van hun loopbaan.

Zestien masterstudenten van verschillende studies helpen de Politie Den Haag nieuwe aanknopingspunten te vinden bij een cold case.

Deze week sluiten we het academisch jaar af met verschillende FGGA-studenten, waarin zij hun zomer- en toekomstplannen vertellen, maar ook terugblikken op het afgelopen jaar: ‘Ik vond het ontzettend prettig om weer terug te komen naar de fijne sfeer op Wijnhaven.’

Twee Leidse studenten maken kans om de ECHO Award Wetenschappelijk Onderwijs te winnen. Deniz Rana Kuseyri (roepnaam Rana) en Ruşen Koç zijn twee van de zes finalisten voor deze landelijke prijs die ieder jaar uitgereikt wordt aan studenten die diversiteit en inclusie bevorderen binnen hun eigen vak…