What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments

In this dissertation non-parametric Bayesian methods are used in the application of robotic vision.

Klimaatinterventies leiden niet tot meer klimaatactie onder Nederlanders, maar ze vergroten wel het bewustzijn over klimaatverandering.

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

This dissertation explores how Large Language Models (LLMs) can effectively and responsibly contribute to complex decision-making processes. By combining AI and human intelligence, Hybrid Intelligence (HI) emerges, allowing the strengths of both humans and machines to be utilized.

Promotor: J. Schaye

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Op 28 oktober 2021 verdedigde Hein van der Bruggen zijn proefschrift en behaalde daarmee de doctorstitel.

Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

This thesis manuscript explores the use of video games as tools for conceptual exploration and academic research.

Promotor: Prof.dr. K.J. Batenburg

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

This thesis describes a study from both a theoreticaL and an experimental point of view.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Promotor: K.E. Schalm, Co-promotor: S.S. Lee

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

Promotor: E.F. Smets Co-promotor: J. Geml

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier