Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Timo Slootweg, associate professor at he department Philosophy of Law, published a chapter about Paul Scholten in

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Promotor: G.R. de Snoo Co-promotor: C.J.M. Musters

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

Promotor: Prof.dr. C.U. Keller

This thesis aims to address offshore wind energy (OWE)-related environmental impacts.

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Promotor: J. Kuiper

Promotor: G.P. van Wezel

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Promotores: T.H. Oosterkamp, N. de Jonge

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Promotor: J. Zaanen

Including modelling as part of software development appears to have various benefits.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

Hoe kunnen theorieën over moderne desinformatie helpen om te begrijpen hoe dat werkte in de Romeinse tijd?

This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…

In this thesis we push the boundaries of high-resolution imaging at radio frequencies between 100 and 200 MHz. Using the International LOFAR Telescope that spans across Europe we achieve sub-arcsecond angular resolution.

The thesis describes experimental steps towards reduction of friction on the macroscopic scale by scenarios of thermo- and superlubricity well-known on the nanoscale.

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Promotor: J.M. Memelink

Dit is een vergelijkende studie naar het proces van omzetting of herroeping van vrijheidsbeperkende sancties in 10 Europese landen.

Kevin speelt hedendaags repertoire dat zich onderscheidt doordat de lichamelijk handelingen die nodig zijn om deze muziek uit te voeren in de notatie van elkaar losgekoppeld zijn. Dit heet ook wel physical polyphonic notations, een unieke en relatief recente trend in de muziek waarbij naast de noten…

The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Chronische pijn, misselijkheid of braken door chemotherapie. Als je er last van hebt, kan medicinale cannabis een uitkomst zijn. Het nadeel is alleen wel dat patiënten er high van kunnen worden. Leidse onderzoekers van het Oncode Instituut doen daarom onderzoek naar alternatieven waar je dat niet van…

On January 8 and 9, a conference will take place at Leiden University, titled: "The Plurality of Early Modern Media: 21st-Century Perspectives on Interdisciplinary Research in the Humanities". This conference marks the 25 years anniversary of the Intersections series (published by Brill) and reflects…

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

De specialisatie Politics, Culture and National Identities, 1789 to the Present (research) van de Universiteit Leiden brengt je in de voorhoede van de nieuwe benadering van de manier waarop in Europa politiek en identiteit worden opgevat.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Online cursus The Importance and Power of Music in our Society

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.