Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

De afdeling Beleid en Innovatie van het Instituut Bestuurskunde richt zich op het vormgeven, implementeren en evalueren van beleid met innovatieve benaderingen. Ons doel is om complexe maatschappelijke uitdagingen aan te pakken door technologische vooruitgang en creatieve beleidsinstrumenten te onde…

Promotor: Prof.dr. M.K. Richardson

Promotor: V. Vitelli, Co-promotor: J. Paulose

Promotor: Prof.dr. E. F. van Dishoeck

DSE 2.0: Naar een optimaal ontwerp van complexe, gedistribueerde cyber-fysieke systemen

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

Consequences for sediment stability and seston trapping

Harm Beukers, Leids emeritus hoogleraar Geschiedenis van de geneeskunde, krijgt de Japanse Orde van de Rijzende Zon met gouden stralen.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Terrorisme destabiliseert regeringen, ondermijnt de burgermaatschappij, bedreigt sociale en economische ontwikkeling, brengt democratie in gevaar en heeft een directe impact op mensenrechten. De buitengewone gebeurtenissen op 9/11 veranderden terrorismebestrijding in een wereldwijd bestuursproject.…

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

For optimization problems, it is often unclear how to choose the most appropriate optimization algorithm. As such, rigorous benchmarking practices are critical to ensure we can gain as much insight into the strengths and weaknesses of these types of algorithms.

Planets are formed in disks of gas and dust around young stars.

Dit rapport gaat in op vragen als

Promotor: Prof.dr. S. Haring

Het P.J. Cosijn Research Fellowship is een initiatief om veelbelovende BA- en MA-studenten van de Universiteit Leiden met interesse in Angelsaksische studies de kans te geven onderzoek te doen naar Oudengelse taal- en letterkunde. De Cosijn Fellowships zijn onderdeel van het door ERC gefinancierde project…

Het NIMAR deelt, net als andere universitaire instituten, betrouwbare en hoogwaardige academische kennis, resultaat van onderwijs en onderzoek, met de samenleving.

Cardiovascular disease is the leading cause of death worldwide.

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

This dissertation presents the synthesis and evaluation of antibody recognition for various capsular polysaccharide (CP) fragments of Staphylococcus aureus (S. aureus).

This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.

Carbonaceous asteroids preserve a record of early solar system processes, where minerals and organic molecules, like polycyclic aromatic hydrocarbons (PAHs), offer clues to planetary evolution and prebiotic chemistry.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

In light of climate change, it is crucial to determine whether plant species can adapt to future climates to avoid extinction. Plants adapt to various conditions by altering their functional traits, such as leaf size or photosynthetic rate. Some traits appear linked and vary together between species,…

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

Promotor: J. N. Kok, Co-promotor: A. J. Knobbe

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

With the dramatic growth of the image data on the web, there is an increasing demand of the algorithms capable of understanding the visual information automatically.

Nieuwe publicatie in de reeks Politiewetenschap van het Programma Politie en Wetenschap.

Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius