Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

Supply risks are not new. But the aggravation of power conflicts on the international stage coupled with global shifts towards energy transition and digitalization has triggered the next supply risk research era.

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Bevorderen van studentenwelzijn en ontwikkeling van soft skills.

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

Om te worden toegelaten tot Geschiedenis van Nederland in de Wereld aan de Universiteit Leiden, moet je aan de onderstaande toelatingseisen voldoen.

Het Leiden University College (LUC) biedt Bachelor of Arts (BA) en Bachelor of Science (BSc) diploma’s aan binnen het Liberal Arts & Sciences programma dat zich richt op vier Mondiale Uitdagingen: Vrede en Recht, Duurzaamheid, Welvaart en Diversiteit. De leeromgeving van het programma wordt gekenmerkt…

The minor Artificial Intelligence & Business (previous name Science, Business, and Innovation) will provide you with knowledge and skills in the area of management and entrepreneurship, with a focus on issues in technology-driven companies.

The Minor in Business Administration teaches business knowledge and skills that are important for your future career.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Heart failure is a major health care problem with high mortality.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Promotor: Prof.dr. H.J.A. Rottgering

Promotor: Prof.dr. T. Hankemeier

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Control of infectious diseases poses continuous challenges for human health.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.

Promotor: B.van de Water, Co-promotor: L.S.Price

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

Cardiovascular syndromes are the major cause of death in Western societies.

De beschrijvende taalkunde aan het LUCL omvat de documentatie en de beschrijvende analyses van minder-bestudeerde talen en de typologische en historische vergelijkingen tussen talen.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae