Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

De Leidse chemicus Sascha Hoogendoorn ontwikkelde synthetische moleculen die selectief worden opgenomen door bepaalde celtypes. Een belangrijke stap in de ontwikkeling van medicijnen met minimale bijwerkingen. Promotie 23 januari.

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

Op 11 november organiseerde de bacheloropleiding Molecular Science and Technology een corona-proof diploma-uitreiking met een bijzondere afstudeerder: de 18-jarige Ruard van Workum. Al van jongs af aan ontwikkelde Ruard een passie voor scheikunde. Hij begon op 15-jarige leeftijd met de opleiding Molecular…

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

This thesis is an experimental study of the UV irradiation of the interstellar ice analogues, relevant for the different stages of the star and planet formation sequence.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

The space between the stars isn't simply a void; it also contains substances such as methanol and carbon dioxide. So far, chemical theories have been unable to explain how these substances originate under circumstances that should make it impossible. Fedor Goumans has been awarded a Veni subsidy to…

Promotor: Prof.dr. H.L.V. Linnartz

Laboratory, observation and modeling work on the dissociation of polycyclic aromatic hydrocarbons in interstellar environments and the formation of new molecular species through the fragmentation process.

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Is het mogelijk om ziektes te diagnosticeren met behulp van moleculaire schakelaars? Over die vraag buigt het nieuwe internationale consortium LogicLab zich. Vanuit Leiden zijn scheikundige Sylvestre Bonnet en farmacoloog Thomas Hankemeier betrokken. Het project loopt voor vier jaar en krijgt ruim 3,5…

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

Promotor: Prof.dr. E. Smets, M. Stech

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

This thesis is about the study of hydrocarbons via infrared spectroscopy.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

The adsorption of D2 and CO2 on catalyst surfaces is studied using a molecular beam in ultra-high vacuum.

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

Veel biologen en medici gebruiken suikers in hun onderzoek, maar de synthese ervan is nog grotendeels onbegrepen. Jeroen Codée heeft een Vici-beurs van 1,5 miljoen euro gekregen om de productie van suikers op een systematische manier te onderzoeken. ‘Ik wil de reacties echt gaan begrijpen.’

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

Promotor: Prof.dr. E. F. van Dishoeck

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

This thesis describes a study from both a theoreticaL and an experimental point of view.

Promotor: H.V.J. Linnartz

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

Gist, alpaca’s en antilichamen. Ze lijken misschien niets met elkaar te maken te hebben, maar binnen het project van de Leidse iGEM-studenten komen ze perfect samen. Voor de internationale synthetische biologiewedstrijd iGEM werkt het team aan een innovatieve methode om nanobodies, een speciale vorm…

Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

Een team van 13 studenten doet mee aan iGEM 2023, een internationale biologiewedstrijd die studenten uitdaagt oplossingen te bedenken voor wereldproblemen. Het team van de Universiteit Leiden heeft de hele zomer gewerkt aan een oplossing voor microplastics in de landbouw, vertellen studenten Sophie…

Antibioticaresistentie is een economisch probleem. Farmaceuten investeren er weinig in. Daarom is het volgens Ned Buijs belangrijk dat universiteiten dit doen.