This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

This thesis aims to address offshore wind energy (OWE)-related environmental impacts.

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

Promotor: Prof.dr. B. van de Water

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

Bereid je voor op de MSc Nationalism, Ethnic Conflict and Development aan Universiteit Leiden met oriëntatieprogramma’s, studiebronnen, visumondersteuning en studentenbegeleiding.

Met ingang van 1 april 2018 is Erik Danen benoemd tot hoogleraar Cancer drug target discovery bij het Leiden Academic Centre for Drug Research (LACDR). Zijn vakgebied is celbiologie van kanker, waarin hij zich richt op de achterliggende mechanismen bij uitzaaiingen en resistentie voor behandelingen.

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

This study tests whether behavioural problems at a young age are related to early reading and mathematics development.

This thesis describes how different colours of light affect various aspects of the growth and development of Arabidopsis and tomato plants⁠.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

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The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.

Het onderzoek dat in dit proefschrift wordt beschreven gaat over de ontwikkeling van praktijkkennis van ervaren natuurkunde-, scheikunde -en biologiedocenten in de context van de invoering van het vak Algemene Natuurwetenschappen (ANW) in de Tweede Fase van het voortgezet onderwijs.

Met meer dan 20.000 Omaanse studenten die Britse programma's volgen in 2017/2018, is het aantal transnationale studenten vrij aanzienlijk in Oman. De transnationale leeromgeving is nieuw voor praktisch al het onderwijzend personeel en voor de studenten. Antonia Lamers onderzocht hoe een TNE-onderwijs-…

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Lesgeven is een complex beroep. Docenten nemen veel beslissingen, bijvoorbeeld over wat ze onderwijzen, hoe ze dit gaan onderwijzen en hoe ze hun lessen kunnen aanpassen aan de behoeften van leerlingen. Dit vraagt een voortdurende ontwikkeling van nieuwe kennis en vaardigheden om expertise in alle facetten…

There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

De Edinburgh Medal 2016 is uitgereikt aan zowel Kevin Govender van de Office of Astronomy for Development (OAD) als de International Astronomical Union (IAU). De prijs is een erkenning voor het wereldwijd bevorderen van onderwijs en technologie door middel van sterrenkunde. Het programma is het geesteskind…

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

Promotor: Prof.dr. B. van de Water

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Dit proefschrift omvat vier deelstudies waarin de ‘pedagogische vakkennis’ (pedagogical content knowledge ofwel PCK) van bètadocenten wordt onderzocht.

To maximise your personal development, we ensure tutorials are small-scale and staff members extremely accessible. In year one, you’ll have an average of 12 contact hours, half of which comprise lectures (in English) and the remainder tutorials (optionally Dutch or English).

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Hoe gaan Chinese taalleraren om met wie ze zijn als leraar als ze in het buitenland werken? Dit proefschrift biedt heldere, praktijkgerichte antwoorden. Het onderzoekt de identiteit van de leraar - het alledaagse antwoord op de vraag 'Wat voor soort leraar ben ik hier?' - terwijl deze wordt beïnvloed…

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In dit onderzoek wordt hersenontwikkeling voor het eerst direct gelinkt aan sekseverschillen en schoolprestatie. De resultaten ontkrachten de mythe dat jongens achterlopen in hersenontwikkeling.

Students with learning problems experience difficulties in reading, writing, and content-area learning into and throughout their secondary-school years

Promotor: Prof.dr. J.N. Kok