Promotor: Prof.dr.ir. E. Deprettere

The space between the stars isn't simply a void; it also contains substances such as methanol and carbon dioxide. So far, chemical theories have been unable to explain how these substances originate under circumstances that should make it impossible. Fedor Goumans has been awarded a Veni subsidy to…

Promotor: Prof.dr. H.L.V. Linnartz

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Als ouders in angstige bewoordingen praten over nieuwe situaties, bepaalt dat sterk hoe vermijdend of angstig hun kind zal reageren. Een angststoornis bij de ouder of angstige aanleg van het kind versterkt dit effect echter niet. Leidse onderzoekers publiceerden hierover in Clinical Child and Family…

Laboratory, observation and modeling work on the dissociation of polycyclic aromatic hydrocarbons in interstellar environments and the formation of new molecular species through the fragmentation process.

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

Promotor: Prof.dr. E. Smets, M. Stech

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

Op 11 november organiseerde de bacheloropleiding Molecular Science and Technology een corona-proof diploma-uitreiking met een bijzondere afstudeerder: de 18-jarige Ruard van Workum. Al van jongs af aan ontwikkelde Ruard een passie voor scheikunde. Hij begon op 15-jarige leeftijd met de opleiding Molecular…

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

This thesis is about the study of hydrocarbons via infrared spectroscopy.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

The adsorption of D2 and CO2 on catalyst surfaces is studied using a molecular beam in ultra-high vacuum.

Twee jonge excellente chemici, Jeroen Codée en Sander van Kasteren, hebben een ECHO subsidie van € 260.000 euro toegekend gekregen door de Nederlandse Organisatie voor Wetenschappelijk Onderzoek. Hiermee kunnen hun onderzoeksprojecten van start gaan.

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Promotor: Prof.dr. H.S. Overkleeft

Promotor: A.P. IJzerman

Promotor: A.P. IJzerman

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

Promotor: Prof.dr. E. F. van Dishoeck

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

This thesis describes a study from both a theoreticaL and an experimental point of view.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

Promotor: H.V.J. Linnartz

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…