Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Promotor: B. van de Water, Co-promotor: E.H.J. Danen

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Galaxies in the Universe are distributed along the intricate framework of the Cosmic Web. Groups and clusters of galaxies comprise the densest regions in this network, and therefore, are excellent cosmic laboratories to study different aspects of galaxy evolution in extreme environments.

Promotor: Prof.dr. M. Ubbink

During the course of drug discovery translational steps are made.

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk

We prove a p-adic version of the work by Gross and Zagier on the differences between singular moduli by proving a set of conjectures by Giampietro and Darmon, who investigated the factorisation of a rational invariant associated to a pair of CM-points on a genus zero Shimura curve, obtained as the ratio…

Studievoorlichting

Understanding how chemical complexity emerges during star formation requires connecting molecular material preserved in interstellar ices with that observed in the gas phase after protostellar heating begins.

The basic program comprises a total of twelve courses organized by the Research School, that have been purpose-developed for training and support of PhD students and Research MA students who specialize in Medieval Studies (history, art history, and literary history, in particular).

Marlisa den Hartog, research master-studente Geschiedenis aan de Universiteit Leiden, heeft de Volkskrant-IISG Scriptieprijs voor Geschiedenis 2016 gewonnen voor haar scriptie The Pleasure that is taken in bed. Perceptions of sexual desire an sexual identity in Italy, 1450-1500.

Sinds 2009 behaalden 95 kandidaten hun doctoraat in Creative en Performing Arts. Op deze pagina een overzicht van ACPA's alumni.

Een masteropleiding vergroot je kansen op de arbeidsmarkt en opent deuren naar uitdagende functies. Na je driejarige bachelor kun je direct doorstromen naar een één- of tweejarige master aan de Universiteit Leiden of een andere instelling.

Een masteropleiding vergroot je kansen op de arbeidsmarkt en opent deuren naar uitdagende functies. Na je driejarige bachelor kun je direct doorstromen naar een één- of tweejarige master aan de Universiteit Leiden of een andere instelling.

Een masteropleiding vergroot je kansen op de arbeidsmarkt en opent deuren naar uitdagende functies. Na je driejarige bachelor kun je direct doorstromen naar een één- of tweejarige master aan de Universiteit Leiden of een andere instelling.

The extensive use of electronic communication channels and other devices has opened new possibilities for collecting data on human behavior. This information is sometimes openly accessible, but largely part of administrative registration systems that are not open to the broader public. The data provides…

Een masteropleiding vergroot je kansen op de arbeidsmarkt en opent deuren naar uitdagende functies. Na je driejarige bachelor kun je direct doorstromen naar een één- of tweejarige master aan de Universiteit Leiden of een andere instelling.

Quantummechanica voor iedereen

Op 10 november 2021 verdedigde Carmel van Niekerk-Jacobs het proefschrift 'Realising the right to reproduce with assistance in South Africa'. Het promotieonderzoek is begeleid door prof.dr. J.J. Sloth-Nielsen en prof.dr. T. Liefaard.

Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Universite Bordeaux I)

This project uses archaeological, literary and epigraphic evidence to investigate urban development in Roman-period North Africa, compiling this in a GIS-linked database in order to analyse the development of urban settlement spatially over time.

Computational thinking, programming, and algorithms form the basic of many of the things that are shaping our world, the way we work, interact, organize ourselves, and even spend our free time with social networks, streaming media, and games. And this transformation is far from being complete, it is…

Kunst en vrije tijd, Kunst en vrije tijd

This dissertation revolves around the design and implementation of novel instrumentation and related measurement techniques, at the single molecule level, for use in biophysical research. Chapter 1 presents an introduction to the field of fluorescence-based single molecule measurements. In particular,…

Promotor: Prof.dr. L.J. Slikkerveer

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Promotor: C. W. J. Beenakker, Yu. V. Nazarov, Co-promotor: J. Tworzydlo

This research delves into a region of space known as the interstellar medium (ISM), which is essentially the area between the stars filled with gas and dust.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Promotor: R.D. Gill, F. Taroni

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.