Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

Our recent excavations have focused on the more recent New Kingdom/Late Period (ca. 1500-332 BCE) material.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

Promotor: W.T. de Groot

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

Studievoorlichting

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

Make more fluid: In condensed matter systems, electrons can acquire unusual properties from their interaction with the atomic lattice.

Forming at the nodes of the Cosmic Web and growing hierarchically via mass accretion, galaxy clusters are the largest virialized halos in our universe, composed of dark matter (DM; ≥85%), ionized hot plasma in the intracluster medium (ICM; ≥10-15%), and galaxies (≥1-5%).

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Taking as a point of departure the Italian American community in Boston and its process of collective remembrance surrounding Saint Anthony’s Feast, we addressing the limits and potential of montage.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Promotie

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

Op 1 juni 2022 verdedigde Tom Herrenberg het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. P.B. Cliteur en prof.dr. B.R. Rijpkema.

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Promotor: Prof.dr. S. Haring

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn

Supply risks are not new. But the aggravation of power conflicts on the international stage coupled with global shifts towards energy transition and digitalization has triggered the next supply risk research era.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

Promotor: Prof.dr. A.G.G.M. Tielens

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

Sinds de 16e eeuw hebben religieuze overwegingen de studie van het Oudengels en zijn sprekers gemotiveerd. In de 19e eeuw wendden geleerden zich vooral tot de studie van de Oudengelse literatuur om sporen te vinden van voorchristelijke, 'Germaanse' religie, zoals besproken in Eric G. Stanley's baanbrekende…

This pioneering project will answer this question by examining migrants through the eyes of the courts between 1600 and 1900. It aims to reveal patterns of continuity and change in: 1. Treatment of migrants by criminal courts; 2. Violence and conflicts between migrants and native born.

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)

The first direct detection of gravitational waves opened the possibility of mapping the Universe via this new and independent messenger.

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

Sager, Overeem en anderen onderzoeken of het gedeelde idee van een ‘rijksambtenaar’ in Europa bestaat.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Eva Michaels & Monika Sus onderzoeken Europese Strategische Autonomie als reactie van de EU op de fragmentatie van de Liberale Internationale Orde.

This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.

LUGO breidt de Green Teams uit over de hele universiteit, te beginnen met de Faculteit der Rechtsgeleerdheid, en nu met teams voor de Archeologie Faculteit en de campus in Den Haag.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros