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At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Onderzoek aan LUC past binnen het algemene kader van de wereldwijde uitdagingen die centraal staan in ons onderwijsprogramma. Het richt zich op belangrijke maatschappelijke vraagstukken, waaronder Vrede & Recht, Diversiteit, Welvaart en Duurzaamheid.

Promotor: Prof.dr. T. Schmidt

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotor: Prof.dr. G.P. van Wezel

Waarom zijn transnationale en interculturele agenten zoals Henrich Carloff en Willem Leyel belangrijk voor de studie van de vroegmoderne expansie?

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Bij uitgeverij Hart uit Oxford verscheen het eerste deel van een (Engelstalige) reeks boeken onder de titel ‘Restatement of Labour Law in Europe’. Dit deel heeft betrekking op de vraag welke werknemer door het arbeidsrecht wordt beschermd (‘The concept of employee’).

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Promotor: A. Kros

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…

The project Multimedia Research and Documentation of African Oral Genres: Connecting Diasporas and Local Audiences (Director: D.Merolla) focuses on multimedia as technology that allows scholars to share documentation and scientific knowledge with the cultural owners of the collected oral genres.

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

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Samenwerking vormt de kern van ons werk binnen het thema 'Health and well-being in a healthy society'.

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

Universiteit Leiden biedt je diverse diensten aan op het gebied van carrièreoriëntatie en sollicitatievaardigheden.

Leiden is een echte studentenstad. Meld je aan voor een studievereniging of studentenvereniging om van jouw studietijd een onvergetelijke tijd te maken!

Ontdek de carrièremogelijkheden na de MSc Nederlandse Politiek aan Universiteit Leiden: functies binnen politiek, beleid, onderzoek, advies en internationale organisaties.

Bewoners (en wetenschappers) telden tijdens Expeditie Stadsnatuur elke spin, slak, paddenstoel of paardenbloem die ze tegenkwamen. Het doel: samen 2025 verschillende soorten vinden.

In 'Bedrijfsovername' vertellen experts uit de wetenschap en praktijk over de bedrijfsovername, een wezenlijk onderdeel van de ondernemingsrechtpraktijk.

LUCSoR heeft leerstoelen in Vergelijkende Religiewetenschappen, Islam en het Westen, en de geschiedenis van het Christendom. Onze belangrijkste expertisegebieden zijn en Islamstudies, nieuwe spirituele bewegingen, hindoeïsme, boeddhisme, Chinese religies, West-Afrikaanse religies, antieke godsdiensten…

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Ruim 30 leden van Opleidingscommissies, Faculteitsraden en Universiteitsraad kwamen op 27 november online bijeen met als missie: hoe kan universitaire medezeggenschap werken aan een duurzamere universiteit in onderwijs, onderzoek en bedrijfsvoering? Het Leiden University Green Office en de Universiteitsraad…

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.