Surface acoustic waves (SAWs) are mechanical waves that travel along the surface of a material and find many applications in modern technologies due to the ease of excitation on piezoelectric substrates via interdigital transducers (IDTs).

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

This thesis addresses the challenge of sustainable urban development by analyzing the interplay between green and grey infrastructure to optimize resource use and ecosystem services.

Onze gemiddelde leeftijd gaat omhoog en de behoefte naar goede gezondheidszorg wordt steeds groter. Nieuwe medicijnen moeten op de markt komen maar kosten voor de ontwikkeling daarvan moeten omlaag. Tijdens het Medical Delta café op 8 oktober presenteren o.a. dr. Leo Price, dr. Jan de Sonneville en…

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Promotor: M.A.G.J. Orrit

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Kijk hier de colleges terug die hoogleraar Design Timo de Rijk gaf in de week van 5 t/m 9 oktober bij de Universiteit van Nederland. In de colleges van De Rijk vind je antwoorden op vragen als: 'Hoe werd de Nederlandse huisvrouw bevrijd?' en 'Hoe stalen wij de fiets van de Britten?' Een must see!

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

This thesis surveys the intersection of computed tomography (CT) and machine learning (ML), treating CT as an ill-posed inverse problem shaped by object properties, imaging physics, and data limitations.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.

Op deze pagina vind je de opnames van de Tuesday Talks sinds april 2025. Ook de opnames van de voorloper van de Tuesday Talks, This Week’s Discoveries, zijn hier te vinden

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

Promotor: A. Kros

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Onderzoekers in Leiden, onder leiding van Sebastian Pomplun, hebben een nieuwe methode ontwikkeld om honderdduizenden moleculen te screenen voor geneesmiddelenonderzoek — dit keer zonder DNA-tags, maar met massaspectrometrie. ‘We wilden geneesmiddelenonderzoek sneller en toegankelijker maken,’ zegt…

Minister Grapperhaus wil inlichtingendiensten bij de opsporing van drugscriminaliteit inzetten. In de inlichtingenwereld bestaan veel aarzelingen over deze wens. Paul Abels, Bijzonder Hoogleraar Governance of Intelligence and Security Services aan het Insitute of Security and Global Affairs (ISGA) spreekt…

Katharina Krüsselmann, promovendus aan het Institute of Security and Global Affairs, sprak bij Omroep Brabant over schietincidenten in Nederland, het onderwerp van haar promotieonderzoek.

Promotores: S.J. Edixhoven, P.Parent

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Een Nederlands consortium ontvangt 6,7 miljoen euro om samen met patiënten het ontwikkelen van nanomedicijnen te versnellen. Onderzoekers van de Universiteit Leiden spelen daarbij een belangrijke rol.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

This thesis manuscript explores the use of video games as tools for conceptual exploration and academic research.

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

The ability to count is a property not often attributed to materials, despite the abundance of memory in materials. Regardless of how a material stores information, it is often difficult to retrieve exactly ‘what’ a material remembers.