Het belangrijkste doel is het onderzoeken van de mogelijkheid om het lichaam te leren een soortgelijke fysiologische (autonome, neuro-endocriene of immuunsysteem) en fysieke (b.v. desensibilisatie van hardnekkige lichamelijke symptomen) reactie te laten vertonen op placebomedicatie als op actieve medicatie…

Op zondag 14 september werd in Den Haag de Vredesloop georganiseerd. Met dit hardloopevenement in het kader van het Just Peace festival werd geld ingezameld voor UNICEF Nederland. Ook een groot team van de Universiteit Leiden liep mee - met succes!

Informatiesessie

EUMOTIONS onderzoekt welke rol emoties van politieke elites (op EU- en lidstaatniveau) spelen in het formuleren van beleidsmogelijkheden van de EU tijdens internationale crises.

Terwijl crises als gevolg van terrorisme, burgeroorlogen en natuurrampen het wereldnieuws domineren, is het niet vreemd dat veiligheid en crisismanagement - inclusief de perceptie van risico's - boven aan de maatschappelijke en bestuurlijke agenda's staan.

For questions and suggestions regarding the series, please contact prof. dr. Olaf van Vliet or dr. Max van Lent

Boekpresentatie

Prof. dr. ir. Bas Rietjens van de Nederlandse Defensie Academie (NLDA) is benoemd tot bijzonder hoogleraar Intelligence in War and Conflict aan het Institute for Security and Global Affairs (ISGA) van de Universiteit Leiden. De aanstelling van Rietjens is een gevolg van de intensievere samenwerking…

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: Prof.dr. M. Danhof

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

This article 'Shaping the European External Action Service and its post-Lisbon crisis management structures: an assessment of the EU High Representatives’ political leadership' assesses the role, influence and core aspects of the EU High Representatives’ (HR/VPs) “political leadership” in the context…

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Heterogeneous catalysis is essential to many industrial applications. These catalysts are often comprised of supported nanoparticles, which contain various different surface sites.

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

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Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

Bij de Onderzoeksgroep Geweld en Geweldpreventie (Violence and Violence Prevention) wordt onderzoek gedaan naar de complexiteit van hedendaags geweld, de uiteenlopende verschijningsvormen ervan en strategieën voor preventie.

Global Environmental Extensions Multi-Regional Input-Output (EE-MRIO) analysis is often used to analyze how changes in global and national demand for products lead to socioeconomic and environmental impacts at the national level.

Promotores: Wim Jiskoot; Ferry Ossendorp

Cardiovascular syndromes are the major cause of death in Western societies.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Promotor: V. Vitelli, Co-promotor: J. Paulose

De afdeling Environmental Biology (CML-EB) houdt zich bezig met vraagstukken rondom biodiversiteit en natuurlijke hulpbronnen op het platteland in westerse en niet-westerse gebieden.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte