The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

This thesis focus on the interaction between M dwarf stellar winds and Galactic cosmic rays and the possible effects on the habitability of exoplanets.

Identification of the products or product groups that have the greatest environmental impact from a life-cycle perspective using environmentally extended input-output analysis.

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Let A be a commutative algebraic group over a field K, and let G be a finitely generated subgroup of the K-rational points of A. The purpose of this thesis is to study the degrees of the Kummer extensions relative to A,K and G.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

In unconventional high temperature superconductors, supercurrent vortices are known to spoil the Landau levels. In this thesis the emergence of Landau levels is studied in different types of superconductors: Weyl superconductors, and the Fu-Kane heterostructure.

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

Sociale Wetenschappen, Politieke Wetenschap

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

Op 21 maart 2019 verdedigde James Welch zijn proefschrift 'The Grotius Sanction: Deus Ex Machina. The legal, ethical, and strategic use of drones in transnational armed conflict and counterterrorism'. Het promotieonderzoek is begeleid door promotor prof. dr. P.B Cliteur.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Promotor: V. Vitelli, Co-promotor: J. Paulose

Bij de afdeling Jeugdrecht en het Grotius Centre for International Legal Studies van de Universiteit Leiden kunt u zich vanaf nu aanmelden voor de Frontiers of Children’s Rights in the Caribbean Region Spring School.

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Op 31 januari 2024 verdedigde Alex Schilin zijn proefschrift 'United in Distinctiveness: The Institutionalisation of Differentiated Integration in Economic and Monetary Union during the Sovereign Debt Crisis'. Wat motiveerde hem om dit onderwerp te onderzoeken en hoe heeft hij dit project aangepakt?…

Overzicht van de vacatures bij de afdeling Economie.

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Promotores: J. Jonkers, K.E. de Visser

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Who are open-source intelligence activists and how reliable are their contributions to public understanding of Russia’s war in Ukraine?

Promotor: Prof.dr.ir. E. Deprettere

Op donderdag 12 januari 2017 verdedigde Ellen Raaijmakers haar proefschrift ‘The Subjectively Experienced Severity of Imprisonment: Determinants and Consequences’. De promotors zijn prof. dr. P. Nieuwbeerta en prof. dr. J.W. de Keijser.