581 zoekresultaten voor “clinical traits” in de Publieke website
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Out for blood: causal inference in clinical transfusion research
Promotie
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Clinical aspects and pathophysiological mechanisms of (systemic) right ventricular failure
Promotie
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Clinical pharmacology studies investigating novel formulations of dopaminergic drugs
Promotie
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Clinical outcomes and graft survival after Descemet membrane endothelial keratoplasty
Promotie
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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Leiden Consortium on Individual Development (L-CID)
Waarom zijn niet alle kinderen even gevoelig voor variaties in hun sociale omgeving?
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Small-molecule inhibitors of bacterial metallo-β-lactamases
The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Onderwijs
De programmagroep Opvoeding en Ontwikkeling is verantwoordelijk voor onderwijs op zowel bachelor- als masterniveau, met speciale aandacht voor opvoeding en ontwikkeling.
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Dynamics of the renin-angiotensin aldosterone system in dogs: circadian variations in physiological conditions and in relation to angiotensin-converting
Promotor: Prof.dr. M. Danhof
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Metabolomics assisted with stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease
The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Algorithms for the description of molecular sequences
Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Towards predictive cardiovascular safety: a systems pharmacology approach
Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Arbeidsmarkt
Met je mastertitel Psychologie op zak ben je klaar voor de arbeidsmarkt. Wat zijn je beroepsmogelijkheden? Waar vind je afgestudeerde psychologen?
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Van de polen tot de tropen: onderzoekers presenteren een unieke databank voor wereldwijde vegetatie
Welke plantensoorten groeien waar - en waarom? In een nieuwe studie in Nature Ecology & Evolution presenteert een internationaal onderzoeksteam 's werelds eerste wereldwijde vegetatiedatabank met meer dan 1,1 miljoen complete lijsten met plantensoorten voor alle terrestrische ecosystemen. Leids hoogleraar…
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Geintje! …?! - Pesten op het werk en mentale gezondheid
Een half miljoen mensen heeft het afgelopen jaar te maken gehad met pesterijen op het werk. Daarvan worden 80.000 mensen structureel vernederd, vermeden, uitgescholden of bedreigd. Wat weten we over het effect van pesten op de werkvloer op onze gezondheid?
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Rankings
Internationale rankings geven geen volledig beeld van de kwaliteit van universiteiten.
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Vervolgopleidingen
Mocht je nog meer verdieping willen na de Academische Pabo, volg dan een masteropleiding. Dat kan aansluitend op je bachelor, maar ook op een later moment - al dan niet in combinatie met een baan.
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Aanpassen of uitsterven – eigenschappen die planten helpen overleven in kaart gebracht
Promovenda Jianhong Zhou wilde beter begrijpen of en hoe plantensoorten zich aanpassen aan bijvoorbeeld klimaatverandering. Ze ontwikkelde twee databanken waarmee ze analyseerde hoe gemakkelijk of moeilijk planten zich aanpassen aan veranderende omstandigheden. Zhou promoveerde op 4 september.
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Staatssecretaris Sander Dekker neemt kennisagenda in ontvangst
Dinsdag 31 januari nam staatssecretaris van Onderwijs, Cultuur en Wetenschap Sander Dekker de nationale kennisagenda Nature4Life in ontvangst. Deze kennisagenda richt zich op onderzoek naar biodiversiteit, ecologie en evolutie en is opgesteld door Naturalis Biodiversity Center en het Netherlands Ecological…
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interventions in an internal medicine clerkship: conquering challenges in the clinical learning environment
Promotie
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Bridging the gap between clinical trials and real-world for advanced melanoma
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mass spectrometry for kidney injury biomarker translation towards the clinical laboratory
Promotie
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Advances in clinical development for vaccines and therapeutics against respiratory virus infections
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Genetic and clinical aspects of inherited syndromes associated with adenomatous polyposis
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Evaluating the microcirculation in early phase clinical trials: novel methodologies and interventions
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on shared decision-making for depression and anxiety disorders in clinical practice
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Clinical pharmacology of antimicrobials, towards optimized treatment of infectious diseases in hospitalized patients
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Early clinical and imaging features of rheumatoid arthritis: Towards a more complete picture
Promotie
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Development of Machine Learning-Derived Digital Biomarkers for Trial@Home Clinical Trials
Promotie
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Metagenomic sequencing in clinical virology: advances in pathogen detection and future prospects
Promotie