Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotie

De eerste ILS Lunch Seminar van 2017 staat gepland voor maandag 30 januari. Tijdens de ILS Lunch Seminars kunnen alle onderzoekers van de faculteit hun onderzoek presenteren. Het doel is om op een toegankelijke en efficiënte manier op de hoogte zijn van onderzoeken van verschillende onderzoeksprogramma's…

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

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Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

Video games have emerged as one of the most interesting media of the turn of the century. The peculiar characteristic of video games is the biunivocal interaction between the computer and the human player.

Planten kunnen zichzelf niet beschermen door van zich af te slaan met scherpe klauwen. Maar toch kan de plant voor hem levensgevaarlijke herbivoren afschrikken. Dat is mogelijk met geuren. Klaas Vrieling van het Instituut Biologie Leiden kwam tot de ontdekking dat evolutie een grote rol speelt om de…

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Schimmels die zich in vanilleplanten nestelen, spelen een rol bij het ontstaan van de smaak en geur van vanille. Dat blijkt uit onderzoek van Shahnoo Khoyratty van het Instituut Biologie Leiden. Promotie op 27 oktober.

Lezing, Studium Generale

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We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

The largest structures in the Universe are clusters of galaxies. Each can contain hundreds to thousands of galaxies.

In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.

Promotores:Th.J.C. van Berkel, M. van Eck

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

In this work the reconstruction of a tau neutrino signal in the KM3NeT detector is discussed.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Studium Generale organiseert academische activiteiten, zoals lezingen, symposia, theatervoorstellingen, filmvertoningen en debatten voor een breed publiek. Het programma van Studium Generale wil vragen stellen en verdieping bieden. Iedereen is welkom, zowel studenten, medewerkers als mensen van buiten…

The research group Science Communication and Society aims to understand how science communication works to improve the interaction between science and society. Central themes are ‘Bridging the gap between experts and the general public’ and ‘Evaluating Science Communication’.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

Promotor: Prof. dr. A.G.G.M. Tielens

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

De Universiteit Leiden heeft heel veel te bieden. Kom kijken, we ontvangen u graag!

Galaxies form and evolve through close interaction with their surroundings. As a result, the heavy elements ('metals') that are synthesized in stars, are found both inside and outside galaxies.

Het Sport Data Center doet onderzoek binnen vijf thema's.

Het onderzoeksproject van Jos Raaijmakers is genomineerd voor de Huibregtsenprijs 2022. De onderzoeker van het NIOO, met gastaanstelling bij het Instituut Biologie Leiden (IBL), is één van de zes genomineerden. Op de Avond van Wetenschap & Maatschappij, 10 oktober 2022, maakt de jury de winnaar beke…

Langs de randen van de Afrikaanse Serengeti groeide de bevolking de afgelopen tien jaar met vierhonderd procent. Het aantal wilde dieren daarentegen nam drastisch af. Van sommige diersoorten bleven er minder dan een kwart over. Ecoloog Michiel Veldhuis onderzoekt of het tij nog te keren is. Hij vertelde…

Twee Leidse onderzoeksprojecten die zich focussen op het vergroten van de biodiversiteit van het Nederlandse productiesysteem voor voedsel en sierteelt, kunnen van start dankzij financiering binnen de KIC-call van NWO.

How should jurisdictions, both on the national and on the supra-national level, handle the interaction between public and private law where it regards the regulation of financial markets?