1,048 zoekresultaten voor “single molecular” in de Publieke website
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Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
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Analysis of the angucycline biosynthetic gene cluster in Streptomyces sp. QL37 and implications for lugdunomycin production
Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.
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Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)
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Contact
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Vervolgopleidingen
Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding. De Universiteit Leiden stimuleert studenten om na hun bacheloropleiding door te gaan met de masteropleiding.
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Disentangling a complex genus: systematics, biogeography and bioactivity of the genus Phyllanthus L. and related genera of tribe Phyllantheae
The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.
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Multifunctional polypept(o)ide miktoarm star polymers for advanced drug delivery: from the development of versatile synthetic strategies for
With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.
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Studium Generale
Studium Generale organiseert academische activiteiten, zoals lezingen, symposia, theatervoorstellingen, filmvertoningen en debatten voor een breed publiek. Het programma van Studium Generale wil vragen stellen en verdieping bieden. Iedereen is welkom, zowel studenten, medewerkers als mensen van buiten…
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Comparative wood anatomy and evolution of Apocynaceae and Sapotaceae
In my research, I used a comparative wood anatomical approach to address wood evolution of the (largely) tropical flowering plant families Apocynaceae and Sapotaceae.
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Arbeidsmarkt
Na de master kiezen de meeste alumni voor een baan in het bedrijfsleven of bij de overheid.
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Spinozapremie voor hoogleraar Spectroscopie Michel Orrit
Mede dankzij de Leidse hoogleraar Michel Orrit is het tegenwoordig mogelijk om losse moleculen te bestuderen. Hij liep de Nobelprijs net mis, maar wordt nu alsnog gelauwerd met een belangrijke wetenschappelijke onderscheiding. Op 16 juni ontvangt hij de Spinozapremie van NWO.
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Archief
Benieuwd naar de afgelopen lezingen? In het archief bewaren wij de presentaties en eventuele verslagen van onze lezingen.
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‘Kijk buiten de eigen vakdisciplines’
Voor goed onderzoek is het nodig om buiten de grenzen van vakdisciplines te kijken, stelt hoogleraar moleculaire en cellulaire biochemie Remus Dame in zijn oratie op 10 mei. Zo zouden processen die plaatsvinden op DNA niet alleen moeten worden onderzocht in een reageerbuis maar ook in levende cellen…
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Leiden - China
China is een belangrijke partner voor de Universiteit Leiden. We werken samen met meer dan 20 Chinese universiteiten en in Leiden studeren zo'n 500 Chinese bachelor-, master- en PhD-studenten. Leiden heeft China aangewezen als prioriteitsland waarmee het een partnerprogramma voor langetermijnsamenwerking…
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ISA – Interventie voor Sociale Angst bij kinderen en jongeren
De sociale angststoornis is één van de meest voorkomende stoornissen bij kinderen en jongeren. Sociale angst wordt gekenmerkt door overmatige angst en vermijding van sociale situaties, waarbij kinderen voornamelijk bang zijn om negatief beoordeeld te worden door anderen. Cognitieve gedragstherapie,…
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Nonparametric Bayesian Methods in Robotic Vision
In this dissertation non-parametric Bayesian methods are used in the application of robotic vision.
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Development of a consistent methodology for assessment of the combined effects of metal-based chemicals to lettuce (Lactuca sativa L.)
Hoe kan de methode om de gecombineerde effecten van metaal-gebaseerde chemische stoffetn te bepalen worden verbeterd?
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Generalized Strictly Periodic Scheduling Analysis, Resource Optimization, and Implementation of Adaptive Streaming Applications
This thesis focuses on addressing four research problems in designing embedded streaming systems.
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Uniform infinite and Gibbs causal triangulations
Promotor: Richard D. Gill
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Probing Molecular Layers with Low-Energy Electrons
Promotie
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Contextual glucocorticoid signaling in-vivo: A molecular perspective
Promotie
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Characterization of DNA-replication proteins and their molecular mechanisms
Promotie
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Updates in Molecular Diagnosis and Targeted Treatment of Thyroid Neoplasia
Promotie
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Understanding anthracycline action: molecular insights to improve cancer therapy
Promotie
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Molecular Diagnostics of Dense Regions in Nearby Galaxies
Promotie
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Studies of dust and gas in the interstellar medium of the Milky Way
Promotor: Prof.dr. A.G.G.M. Tielens
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Activity-Based Proteasome Profiling
Promotor: Prof.dr. H.S. Overkleeft
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Volatile compounds from Actinobacteria as mediators of microbial interactions
Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.
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Isotopes and the characterization of extrasolar planets
Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.
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Group benefits from genomic instability: a tale of antibiotic warriors in Streptomyces
Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.
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Microbial communities in Pampa soils; impact of land use changes, soil type and climatic conditions
Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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Multiple star formation: chemistry, physics and coevality
Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.
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Supramolecular polymer materials for biomedical applications and diagnostics
Self-assembly is an abundant process in nature and is vital to many processes in living organisms.
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Balsaminaceae in Southeast Asia: systematics, evolution, and pollination biology
Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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Multiscale mathematical biology of cell-extracellular matrix interactions during morphogenesis
During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.
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Mining the kinematics of discs to hunt for planets in formation
Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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Systematics, Epidermal defense and Bioprospecting of Wild Orchids
This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.
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Evolutionary Developmental Biology of Bitterling Fish
We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…
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Novel role of the AT-HOOK MOTIF NUCLEAR LOCALIZED 15 gene in Arabidopsis meristem activity and longevity
Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.
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Activity-based protein profiling in drug discovery
In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.
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Simulating the birth environment of circumstellar discs
Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.